Current insights into the expression and functions of tumor-derived immunoglobulins

Numerous studies have reported expressions of immunoglobulins (Igs) in many human tumor tissues and cells. Tumor-derived Igs have displayed multiple significant functions which are different from classical Igs produced by B lymphocytes and plasma cells. This review will concentrate on major progress...

Full description

Saved in:
Bibliographic Details
Published in:Cell death discovery 2021-06, Vol.7 (1), p.148-148, Article 148
Main Authors: Zhao, Jing, Peng, Hui, Gao, Jie, Nong, Anna, Hua, Haoming, Yang, Shulin, Chen, Liying, Wu, Xiangsheng, Zhang, Hao, Wang, Juping
Format: Article
Language:English
Subjects:
692/308/53/2421
692/699/67/580/1884/2323
Apoptosis
Biochemistry
Biomedical and Life Sciences
Cell Biology
Cell Cycle Analysis
Immunoglobulins
Life Sciences
Lymphocytes B
Physicochemical properties
Plasma cells
Review
Review Article
Stem Cells
Citations: Items that this one cites
Items that cite this one
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:Numerous studies have reported expressions of immunoglobulins (Igs) in many human tumor tissues and cells. Tumor-derived Igs have displayed multiple significant functions which are different from classical Igs produced by B lymphocytes and plasma cells. This review will concentrate on major progress in expressions, functions, and mechanisms of tumor-derived Igs, similarities and differences between tumor-derived Igs and B-cell-derived Igs. We also discuss the future research directions of tumor-derived Igs, including their structural characteristics, physicochemical properties, mechanisms for rearrangement and expression regulation, signaling pathways involved, and clinical applications.
ISSN:2058-7716
2058-7716
DOI:10.1038/s41420-021-00550-9