eIF4E as a control target for viruses

Translation is a complex process involving diverse cellular proteins, including the translation initiation factor eIF4E, which has been shown to be a protein that is a point for translational regulation. Viruses require components from the host cell to complete their replication cycles. Various stud...

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Bibliographic Details
Published in:Viruses 2015-02, Vol.7 (2), p.739-750
Main Authors: Montero, Hilda, García-Román, Rebeca, Mora, Silvia I
Format: Article
Language:English
Subjects:
4EBP
cancer
Carrier Proteins
eIF4E
Eukaryotic Initiation Factor-4E - metabolism
Gene Expression Regulation
Host-Pathogen Interactions
latency
Protein Binding
Protein Biosynthesis
Review
translation
Viral Proteins - metabolism
virus
Virus Physiological Phenomena
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Summary:Translation is a complex process involving diverse cellular proteins, including the translation initiation factor eIF4E, which has been shown to be a protein that is a point for translational regulation. Viruses require components from the host cell to complete their replication cycles. Various studies show how eIF4E and its regulatory cellular proteins are manipulated during viral infections. Interestingly, viral action mechanisms in eIF4E are diverse and have an impact not only on viral protein synthesis, but also on other aspects that are important for the replication cycle, such as the proliferation of infected cells and stimulation of viral reactivation. This review shows how some viruses use eIF4E and its regulatory proteins for their own benefit in order to spread themselves.
ISSN:1999-4915
1999-4915
DOI:10.3390/v7020739