Effects of anti-TNF biologic drugs on uveitis severity in Behçet patients: systematic review and Meta-analysis

• Published in: International journal of ophthalmology 2022-05, Vol.15 (5), p.813-819
• Main Authors: Abolhasani, Somayeh, Khabbazi, Alireza, Hosseini, Foroogh, Gholizadeh-Ghaleh Aziz, Shiva, Alipour, Shahriar
• Format: Article
• Language: English
• Subjects: anti-tnf drugs; behçet's disease; infliximab; Meta-Analysis; uveitis; visual acuity
• ISSN: 2222-3959; 2227-4898
• DOI: 10.18240/ijo.2022.05.19

To investigate effects of anti-TNF biologic drugs on uveitis severity (comparing visual acuity logMAR levels) in Behçet patients. Three databases PubMed, Scopus, and the Web of Science were searched for qualified papers focusing on the anti-TNF-α factors treatment in Behçet's disease (BD)-associated uveitis. Studies that were designed pre and post anti-TNF drug treatment, were selected. After determining the search strategy for this study, the relevant data were extracted. The initial search was performed in the target databases and a total of about 1458 articles were found. Fifteen articles were selected for systematic review and only 12 of them had inclusion criteria for Meta-analysis (with visual acuity data). The mean dose of prednisolone before and after biological treatments was reported in 5 studies (28.56 and 7.56 mg/kg, respectively). Also, the preliminary results indicate a significant reduction in visual acuity logMAR levels (MD=-1.5 IU/L, 95%CI: -2.1, -0.01). Biological drugs significantly reduce the dose of prednisolone and affect visual acuity values.