Hemocompatible Chitin-Chitosan Composite Fibers

Composite chitosan fibers filled with chitin nanofibrils (CNF) were obtained by the wet spinning method. The paper discusses the mechanical properties of such type fibers and their hemocompatibility, as well as the possibility of optimizing these properties by adding chitin nanofibrils. It was shown...

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Bibliographic Details
Published in:Cosmetics (Basel) 2020-06, Vol.7 (2), p.28
Main Authors: Maevskaia, Ekaterina N., Kirichuk, Oksana P., Kuznetzov, Sergei I., Dresvyanina, Elena N., Yudin, Vladimir V., Morganti, Pierfrancesco
Format: Article
Language:English
Subjects:
Blood
Chitin
Chitosan
Composite materials
Composition
Electron tubes
Experiments
Fibers
Health aspects
hemocompatibility
Hemoglobin
Hemoglobins
Humidity
Macromolecules
mechanical characteristics
Mechanical properties
Medical equipment
Medical research
Optical density
Plasma
Polymers
Properties
Studies
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Summary:Composite chitosan fibers filled with chitin nanofibrils (CNF) were obtained by the wet spinning method. The paper discusses the mechanical properties of such type fibers and their hemocompatibility, as well as the possibility of optimizing these properties by adding chitin nanofibrils. It was shown that low CNF concentration (about 0.5%) leads to an increase in fiber tensile strength due to the additional orientation of chitosan macromolecules. At the same time, with an increase in the content of CNF, the stability of the mechanical properties of composite fibers in a humid medium increases. All chitosan fibers, except 0.5% CNF, showed good hemocompatibility, even on prolonged contact with human blood. The addition of chitin nanofibers leads to decrease in hemoglobin molecules sorption due to the decline in optical density at wavelengths of 414 nm and 540 nm. Nevertheless, the hemolysis of fibers was comparable or even lesser that carbon hemosorbent, which is actively used in clinical practice.
ISSN:2079-9284
2079-9284
DOI:10.3390/cosmetics7020028