microRNAs: important regulators of stem cells

Stem cells are undifferentiated cells and have multi-lineage differentiation potential. Generally, stem cells are classified into adult stem cells, embryonic stem cells (ESCs) and induced pluripotent stem cells (iPSCs). Stem cells have great potential in clinical therapy due to their pluripotency an...

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Bibliographic Details
Published in:Stem cell research & therapy 2017-05, Vol.8 (1), p.110-110, Article 110
Main Authors: Li, Na, Long, Bo, Han, Wei, Yuan, Shumin, Wang, Kun
Format: Article
Language:English
Subjects:
Aging
Animals
Apoptosis
Cell cycle
Cell fate
Cell self-renewal
Cellular Reprogramming
Differentiation
Efficiency
Embryo cells
Embryonic Stem Cells - cytology
Embryonic Stem Cells - metabolism
Embryos
Evolution
Gene expression
Humans
Induced Pluripotent Stem Cells - cytology
Induced Pluripotent Stem Cells - metabolism
Kinases
MicroRNAs
MicroRNAs - genetics
MicroRNAs - metabolism
miRNA
miRNAs
Pluripotency
Regenerative medicine
Reprogramming
Review
Reviews
Signal transduction
Smooth muscle
Stem cell
Stem cells
Transcription factors
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Summary:Stem cells are undifferentiated cells and have multi-lineage differentiation potential. Generally, stem cells are classified into adult stem cells, embryonic stem cells (ESCs) and induced pluripotent stem cells (iPSCs). Stem cells have great potential in clinical therapy due to their pluripotency and self-renewal ability. microRNAs (miRNAs) are small non-coding RNAs which are evolutionarily conserved and participate in the pathogenesis of many diseases, cell cycle regulation, apoptosis, aging, cell fate decisions, and different signaling pathways. Different kinds of stem cells possess distinct miRNA expression profiles. Our review summarizes the critical roles of miRNAs in stem cell reprogramming, pluripotency maintenance, and differentiation. In the future, miRNAs may greatly contribute to stem cell clinical therapy and have potential applications in regenerative medicine.
ISSN:1757-6512
1757-6512
DOI:10.1186/s13287-017-0551-0