Pyroptosis and degenerative diseases of the elderly

Pyroptosis is a recently described mechanism of programmed cell death mediated by proteins of the gasdermin family. Widely recognized signaling cascades include the classical, non-classical, caspase-3-dependent gasdermin E and caspase-8-dependent gasdermin D pathways. Additional pyroptotic pathways...

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Published in:Cell death & disease 2023-02, Vol.14 (2), p.94-94, Article 94
Main Authors: Zhou, Jiamin, Qiu, Jingjing, Song, Yuwan, Liang, Tiantian, Liu, Sha, Ren, Chao, Song, Xicheng, Cui, Limei, Sun, Yan
Format: Article
Language:English
Subjects:
631/378/1689
631/80/82
Age
Aged
Alzheimer's disease
Antibodies
Apoptosis
Arthritis
Biochemistry
Biomedical and Life Sciences
Caspase-3
Caspase-8
Caspases - metabolism
Cell Biology
Cell Culture
Cell death
Cytokines
Cytotoxicity
Degenerative disc disease
Degenerative diseases
Gasdermins
Humans
Immunology
Inflammasomes - metabolism
Inflammation
Intervertebral discs
Intracellular Signaling Peptides and Proteins - metabolism
Kinases
Life Sciences
Macular degeneration
Neoplasm Proteins - metabolism
Neurodegenerative diseases
Osteoarthritis
Pathogenesis
Pathogens
Phosphate-Binding Proteins - metabolism
Plasma
Proteins
Pyroptosis
Pyroptosis - physiology
Review
Review Article
Tumor necrosis factor-TNF
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container_title Cell death & disease
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creator Zhou, Jiamin
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Song, Yuwan
Liang, Tiantian
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Song, Xicheng
Cui, Limei
Sun, Yan
description Pyroptosis is a recently described mechanism of programmed cell death mediated by proteins of the gasdermin family. Widely recognized signaling cascades include the classical, non-classical, caspase-3-dependent gasdermin E and caspase-8-dependent gasdermin D pathways. Additional pyroptotic pathways have been subsequently reported. With the rising prevalence of advanced age, the role of pyroptosis in the degenerative diseases of the elderly has attracted increased research attention. This article reviews the primary mechanisms of pyroptosis and summarizes progress in the research of degenerative diseases of the elderly such as presbycusis, age-related macular degeneration, Alzheimer’s disease, intervertebral disc degeneration, and osteoarthritis.
doi_str_mv 10.1038/s41419-023-05634-1
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subjects 631/378/1689
631/80/82
Age
Aged
Alzheimer's disease
Antibodies
Apoptosis
Arthritis
Biochemistry
Biomedical and Life Sciences
Caspase-3
Caspase-8
Caspases - metabolism
Cell Biology
Cell Culture
Cell death
Cytokines
Cytotoxicity
Degenerative disc disease
Degenerative diseases
Gasdermins
Humans
Immunology
Inflammasomes - metabolism
Inflammation
Intervertebral discs
Intracellular Signaling Peptides and Proteins - metabolism
Kinases
Life Sciences
Macular degeneration
Neoplasm Proteins - metabolism
Neurodegenerative diseases
Osteoarthritis
Pathogenesis
Pathogens
Phosphate-Binding Proteins - metabolism
Plasma
Proteins
Pyroptosis
Pyroptosis - physiology
Review
Review Article
Tumor necrosis factor-TNF
title Pyroptosis and degenerative diseases of the elderly
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