The Use of Photoactive Polymeric Nanoparticles and Nanofibers to Generate a Photodynamic-Mediated Antimicrobial Effect, with a Special Emphasis on Chronic Wounds

This review is concerned with chronic wounds, with an emphasis on biofilm and its complicated management process. The basics of antimicrobial photodynamic therapy (PDT) and its underlying mechanisms for microbial eradication are presented. Intrinsically active nanocarriers (polydopamine NPs, chitosa...

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Bibliographic Details
Published in:Pharmaceutics 2024-02, Vol.16 (2), p.229
Main Authors: Abdel Khalek, Mohamed A, Abdelhameed, Amr M, Abdel Gaber, Sara A
Format: Article
Language:English
Subjects:
Antimicrobial agents
Bedsores
Biofilms
Blood vessels
chronic wound healing
Cytokines
Debridement
Diabetes
Diabetic foot
electrospun nanofibers
Extracellular matrix
Foot diseases
Growth factors
Immune system
Metabolism
Methicillin
Methylene blue
Microorganisms
Neutrophils
Photodynamic therapy
photodynamic therapy (PDT)
polymeric nanoparticles
Proteins
Review
Skin
Ulcers
Wound healing
Wounds and injuries
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Summary:This review is concerned with chronic wounds, with an emphasis on biofilm and its complicated management process. The basics of antimicrobial photodynamic therapy (PDT) and its underlying mechanisms for microbial eradication are presented. Intrinsically active nanocarriers (polydopamine NPs, chitosan NPs, and polymeric micelles) that can further potentiate the antimicrobial photodynamic effect are discussed. This review also delves into the role of photoactive electrospun nanofibers, either in their eluting or non-eluting mode of action, in microbial eradication and accelerating the healing of wounds. Synergic strategies to augment the PDT-mediated effect of photoactive nanofibers are reviewed.
ISSN:1999-4923
1999-4923
DOI:10.3390/pharmaceutics16020229