Rhythmic oscillations in the midbrain dopaminergic nuclei in mice

Dopamine release in the forebrain by midbrain ventral tegmental nucleus (VTA) and substantia nigra pars compacta (SNc) neurons is implicated in reward processing, goal-directed learning, and decision-making. Rhythmic oscillations of neural excitability underlie coordination of network processing, an...

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Bibliographic Details
Published in:Frontiers in cellular neuroscience 2023-06, Vol.17, p.1131313-1131313
Main Authors: Oberto, Virginie J, Matsumoto, Jumpei, Pompili, Marco N, Todorova, Ralitsa, Papaleo, Francesco, Nishijo, Hisao, Venance, Laurent, Vandecasteele, Marie, Wiener, Sidney I
Format: Article
Language:English
Subjects:
4 Hz
Animals
awake delta rhythm
Decision making
Dental cement
Dopamine
Dopamine receptors
Electrodes
Electrophysiological recording
Excitability
Food
Forebrain
Frequency dependence
Interneurons
Laboratories
Mesencephalon
Neuroscience
Odors
Olfactory discrimination learning
Operant conditioning
Oscillations
Punishment
Rhythm
Rhythms
slow rhythm
Substantia nigra
substantia nigra pars compacta
Unit activity
ventral tegmental area
Ventral tegmentum
Visual discrimination
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Summary:Dopamine release in the forebrain by midbrain ventral tegmental nucleus (VTA) and substantia nigra pars compacta (SNc) neurons is implicated in reward processing, goal-directed learning, and decision-making. Rhythmic oscillations of neural excitability underlie coordination of network processing, and have been reported in these dopaminergic nuclei at several frequency bands. This paper provides a comparative characterization of several frequencies of oscillations of local field potential and single unit activity, highlighting some behavioral correlates. We recorded from optogenetically identified dopaminergic sites in four mice training in operant olfactory and visual discrimination tasks. Rayleigh and Pairwise Phase Consistency (PPC) analyses revealed some VTA/SNc neurons phase-locked to each frequency range, with fast spiking interneurons (FSIs) prevalent at 1-2.5 Hz (slow) and 4 Hz bands, and dopaminergic neurons predominant in the theta band. More FSIs than dopaminergic neurons were phase-locked in the slow and 4 Hz bands during many task events. The highest incidence of phase-locking in neurons was in the slow and 4 Hz bands, and occurred during the delay between the operant choice and trial outcome (reward or punishment) signals. These data provide a basis for further examination of rhythmic coordination of activity of dopaminergic nuclei with other brain structures, and its impact for adaptive behavior.
ISSN:1662-5102
1662-5102
DOI:10.3389/fncel.2023.1131313