Improving cytotoxicity against cancer cells by chemo-photodynamic combined modalities using silver-graphene quantum dots nanocomposites

The combination of chemotherapy and photodynamic therapy has emerged as a promising strategy for cancer therapy due to its synergistic effects. In this work, PEGylated silver nanoparticles decorated with graphene quantum dots (Ag-GQDs) were tested as a platform to deliver a chemotherapy drug and a p...

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Bibliographic Details
Published in:International journal of nanomedicine 2016-01, Vol.11 (Issue 1), p.107-119
Main Authors: Habiba, Khaled, Encarnacion-Rosado, Joel, Garcia-Pabon, Kenny, Villalobos-Santos, Juan C, Makarov, Vladimir I, Avalos, Javier A, Weiner, Brad R, Morell, Gerardo
Format: Article
Language:English
Subjects:
Antineoplastic Agents - administration & dosage
Antineoplastic Agents - chemistry
Antineoplastic Agents - pharmacology
Apoptosis - drug effects
Cancer therapy
Combined Modality Therapy - methods
Doxorubicin - chemistry
Doxorubicin - pharmacology
Drug delivery
Drug Therapy, Combination
Graphene quantum dots
Graphite - chemistry
Graphite - pharmacology
HeLa Cells - drug effects
Humans
Nanocomposites
Nanocomposites - chemistry
Original Research
Photochemotherapy - methods
Photodynamic therapy
Photosensitizing Agents - chemistry
Photosensitizing Agents - pharmacology
Quantum Dots - therapeutic use
Silver - chemistry
Silver - pharmacology
Silver nanoparticles
Singlet Oxygen - metabolism
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Summary:The combination of chemotherapy and photodynamic therapy has emerged as a promising strategy for cancer therapy due to its synergistic effects. In this work, PEGylated silver nanoparticles decorated with graphene quantum dots (Ag-GQDs) were tested as a platform to deliver a chemotherapy drug and a photosensitizer, simultaneously, in chemo-photodynamic therapy against HeLa and DU145 cancer cells in vitro. Ag-GQDs have displayed high efficiency in delivering doxorubicin as a model chemotherapy drug to both cancer cells. The Ag-GQDs exhibited a strong antitumor activity by inducing apoptosis in cancer cells without affecting the viability of normal cells. Moreover, the Ag-GQDs exhibited a cytotoxic effect due to the generation of the reactive singlet oxygen upon 425 nm irradiation, indicating their applicability in photodynamic therapy. In comparison with chemo or photodynamic treatment alone, the combined treatment of Ag-GQDs conjugated with doxorubicin under irradiation with a 425 nm lamp significantly increased the death in DU145 and HeLa. This study suggests Ag-GQDs as a multifunctional and efficient therapeutic system for chemo-photodynamic modalities in cancer therapy.
ISSN:1178-2013
1176-9114
1178-2013
DOI:10.2147/ijn.s95440