Effect of Lactococcus lactis Strain Plasma on HHV-6 and HHV-7 Shedding in Saliva: A Prospective Observational Study

HHV-6 and HHV-7 can reactivate in the salivary gland in response to various host stresses. Lactococcus lactis strain Plasma (LC-Plasma) can activate plasmacytoid dendritic cells (pDCs) and decrease viral infection. We investigated whether LC-Plasma intake could decrease HHV-6 and HHV-7 reactivation...

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Bibliographic Details
Published in:Microorganisms (Basel) 2021-08, Vol.9 (8), p.1683
Main Authors: Miura, Hiroki, Ihira, Masaru, Kozawa, Kei, Kawamura, Yoshiki, Higashimoto, Yuki, Hattori, Fumihiko, Yoshikawa, Tetsushi
Format: Article
Language:English
Subjects:
Age
Dendritic cells
Deoxyribonucleic acid
DNA
Exocrine glands
Genetic testing
HHV-6
HHV-7
Lactococcus lactis
LC-Plasma
Males
Observational studies
Plasma
Saliva
Salivary gland
Salivary glands
Shedding
Subgroups
Viral infections
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Summary:HHV-6 and HHV-7 can reactivate in the salivary gland in response to various host stresses. Lactococcus lactis strain Plasma (LC-Plasma) can activate plasmacytoid dendritic cells (pDCs) and decrease viral infection. We investigated whether LC-Plasma intake could decrease HHV-6 and HHV-7 reactivation in the salivary gland. A total of 54 healthy volunteers were enrolled in this study. Participants took LC-Plasma granules daily for 6 weeks. Saliva samples were collected from subjects weekly for 4 weeks before (first), during (second), and after (third period) LC-Plasma intake. There was a 2-week interval between the first and second periods and a 3-week interval between the second and third periods. Mean salivary HHV-6 and HHV-7 DNA loads were compared among the three observation periods. In the first period (baseline data of viral DNA shedding), HHV-6 DNA shedding was significantly higher in subjects under 40 years old, and HHV-7 DNA shedding was significantly higher in males. HHV-6 and HHV-7 DNA loads did not significantly differ between periods. Meanwhile, in a subgroup analysis of the subjects under 40 years old, HHV-6 DNA load was significantly lower in the second period than in the first period. LC-Plasma decreases HHV-6 reactivation in the salivary glands in younger adults.
ISSN:2076-2607
2076-2607
DOI:10.3390/microorganisms9081683