Advances in Chitosan-Based Nanoparticles for Drug Delivery

Nanoparticles (NPs) have an outstanding position in pharmaceutical, biological, and medical disciplines. Polymeric NPs based on chitosan (CS) can act as excellent drug carriers because of some intrinsic beneficial properties including biocompatibility, biodegradability, non-toxicity, bioactivity, ea...

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Bibliographic Details
Published in:International journal of molecular sciences 2021-09, Vol.22 (17), p.9652
Main Authors: Mikušová, Veronika, Mikuš, Peter
Format: Article
Language:English
Subjects:
Animals
Biocompatibility
Biodegradability
Biological activity
Chitosan
Chitosan - chemistry
Classification
controlled release
Crosslinking
Drug carriers
Drug Carriers - chemistry
Drug delivery
Drug delivery systems
Drug Delivery Systems - methods
Drug Liberation
Drugs
Humans
Hydrophobic and Hydrophilic Interactions
Molecular Structure
Nanocomposites
Nanoparticles
Nanoparticles - chemistry
new formulations
Pharmaceutical industry
Pharmaceutical Preparations - administration & dosage
Pharmaceutical Preparations - chemistry
Physicochemical properties
Polymers
Proteins
Review
targeting
Toxicity
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Summary:Nanoparticles (NPs) have an outstanding position in pharmaceutical, biological, and medical disciplines. Polymeric NPs based on chitosan (CS) can act as excellent drug carriers because of some intrinsic beneficial properties including biocompatibility, biodegradability, non-toxicity, bioactivity, easy preparation, and targeting specificity. Drug transport and release from CS-based particulate systems depend on the extent of cross-linking, morphology, size, and density of the particulate system, as well as physicochemical properties of the drug. All these aspects have to be considered when developing new CS-based NPs as potential drug delivery systems. This comprehensive review is summarizing and discussing recent advances in CS-based NPs being developed and examined for drug delivery. From this point of view, an enhancement of CS properties by its modification is presented. An enhancement in drug delivery by CS NPs is discussed in detail focusing on (i) a brief summarization of basic characteristics of CS NPs, (ii) a categorization of preparation procedures used for CS NPs involving also recent improvements in production schemes of conventional as well as novel CS NPs, (iii) a categorization and evaluation of CS-based-nanocomposites involving their production schemes with organic polymers and inorganic material, and (iv) very recent implementations of CS NPs and nanocomposites in drug delivery.
ISSN:1422-0067
1661-6596
1422-0067
DOI:10.3390/ijms22179652