ADSC Therapy in Neurodegenerative Disorders

• Published in: Cell Transplantation 2014-05, Vol.23 (4-5), p.549-557
• Main Authors: Chan, Tzu-Min, Chen, Julia Yi-Ru, Ho, Li-Ing, Lin, Hui-Ping, Hsueh, Kuo-Wei, Liu, Demeral David, Chen, Yi-Hung, Hsieh, An-Cheng, Tsai, Nu-Man, Hueng, Dueng-Yuan, Tsai, Sheng-Tzeng, Chou, Pei-Wen, Lin, Shinn-Zong, Harn, Horng-Jyh
• Format: Article
• Language: English
• Subjects: Adipose Tissue - cytology; Alzheimer Disease - therapy; Amyotrophic Lateral Sclerosis - therapy; Animals; Cell Differentiation; Cell Lineage; Humans; Huntington Disease - therapy; Neurodegenerative Diseases - therapy; Parkinson Disease - therapy; Stem Cell Transplantation; Stem Cells - cytology
• ISSN: 0963-6897; 1555-3892
• DOI: 10.3727/096368914X678445

Neurodegenerative disorders, chronic diseases that can severely affect the patient's daily life, include amyotrophic lateral sclerosis, Parkinson's, Alzheimer's, and Huntington's diseases. However, these diseases all have the common characteristic that they are due to degenerative irreversibility, and thus no efficient drugs or therapy methods can mitigate symptoms completely. Stem cell therapy, such as adipose tissue-derived stem cells (ADSCs), is a promising treatment for incurable disorders. In this review, we summarized the previous studies using ADSCs to treat neurodegenerative disorders, as well as their therapeutic mechanisms. We also suggested possible expectations for future human clinical trials involving minimized intracerebroventricular combined with intravenous administration, using different cell lineages to finish complementary therapy as well as change the extracellular matrix to create a homing niche. Depending on successful experiments in relevant neurodegenerative disorders models, this could form the theoretical basis for future human clinical trials.