Metabolic unhealthiness is an important predictor for the development of advanced colorectal neoplasia

Obesity is a well-known risk factor for colorectal neoplasia. Yet, the associations of both metabolic and obesity status with metachronous colorectal neoplasia remain unclear. We conducted a cohort study of 9,331 adults who underwent screening colonoscopy and surveillance colonoscopy. Participants w...

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Bibliographic Details
Published in:Scientific reports 2017-08, Vol.7 (1), p.9011-8, Article 9011
Main Authors: Kim, Tae Jun, Kim, Eun Ran, Hong, Sung Noh, Kim, Young-Ho, Chang, Dong Kyung, Ji, Jaehwan, Kim, Jee Eun, Kim, Hye Seung, Kim, Kyunga, Son, Hee Jung
Format: Article
Language:English
Subjects:
692/163/2743/2037
692/163/2743/393
692/4020/1394
692/4028/67/1504/1885
Adenoma
Amine oxidase (flavin-containing)
Body mass
Body mass index
Colon
Colonoscopy
Colorectal cancer
Humanities and Social Sciences
Metabolic disorders
Metabolic syndrome
Metabolism
multidisciplinary
Obesity
Risk factors
Science
Science (multidisciplinary)
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Summary:Obesity is a well-known risk factor for colorectal neoplasia. Yet, the associations of both metabolic and obesity status with metachronous colorectal neoplasia remain unclear. We conducted a cohort study of 9,331 adults who underwent screening colonoscopy and surveillance colonoscopy. Participants were classified as metabolically healthy if they had no metabolic syndrome component. Participants were categorized into four groups according to body mass index and metabolic status: metabolically healthy non-obese (MHNO; n = 2,745), metabolically abnormal non-obese (MANO; n = 3,267), metabolically healthy obese (MHO; n = 707), and metabolically abnormal obese (MAO; n = 2,612). MAO individuals [n = 159 advanced colorectal neoplasia (AN) cases, 6.1%] and MANO individuals (n = 167 AN cases, 5.1%) had a higher incidence of AN compared with MHNO individuals (n = 79 AN cases, 2.9%). In a multivariable model, the risk of metachronous AN was higher in MANO (hazard ratio [HR] 1.43, 95% confidence interval [CI] 1.12–1.84) and MAO (HR 1.52, 95% CI 1.18–1.96) than in MHNO. In contrast, the risk of metachronous AN was not significantly elevated in MHO. In subgroup analyses, with or without adenoma at baseline, MAO was a risk group for metachronous AN, and MHO was not. Our findings suggest that metabolic unhealthiness is a significant predictor for metachronous AN.
ISSN:2045-2322
2045-2322
DOI:10.1038/s41598-017-08964-1