Effect of postmastectomy radiotherapy on pT1-2N1 breast cancer patients with different molecular subtypes

To clarify the effect of postmastectomy radiotherapy (PMRT) on pT1-2N1 breast cancer patients with different molecular subtypes. We retrospectively analyzed the data of 5442 patients with pT1-2N1 breast cancer treated using modified radical mastectomy in 11 hospitals in China. Univariate, multivaria...

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Bibliographic Details
Published in:Breast (Edinburgh) 2022-02, Vol.61, p.108-117
Main Authors: Guo, Xin-Yuan, Sun, Guang-Yi, Wang, Hong-Mei, Liu, Min, Zhang, Yu-Jing, Zhang, Na, Tang, Yu, Zhao, Xu-Ran, Jing, Hao, Fang, Hui, Wen, Ge, Guo, Qi-Shuai, Wu, Hong-Fen, Wang, Xiao-Hu, Ma, Chang-Ying, Li, Ye-Xiong, Cheng, Jing, Shi, Mei, Wang, Shu-Lian
Format: Article
Language:English
Subjects:
1–3 positive lymph nodes
Breast neoplasm
Modified radical mastectomy
Molecular subtype
Original
Radiotherapy
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Summary:To clarify the effect of postmastectomy radiotherapy (PMRT) on pT1-2N1 breast cancer patients with different molecular subtypes. We retrospectively analyzed the data of 5442 patients with pT1-2N1 breast cancer treated using modified radical mastectomy in 11 hospitals in China. Univariate, multivariate, and propensity score matching (PSM) analyses were used to evaluate the effect of PMRT on locoregional recurrence (LRR). With a median follow-up duration of 63.8 months, the 5-year LRR rates were 4.0% and 7.7% among patients treated with and without PMRT, respectively (p 
ISSN:0960-9776
1532-3080
DOI:10.1016/j.breast.2021.12.013