Oncofertility in patients with stage I epithelial ovarian cancer: fertility-sparing surgery in young women of reproductive age

• Published in: World journal of surgical oncology 2017-08, Vol.15 (1), p.154-154, Article 154
• Main Authors: Jiang, Xuan, Yang, Jiaxin, Yu, Mei, Xie, Weimin, Cao, Dongyan, Wu, Ming, Pan, Lingya, Huang, Huifang, You, Yan, Shen, Keng
• Format: Article
• Language: English
• Subjects: Adenocarcinoma, Clear Cell - pathology; Adenocarcinoma, Clear Cell - surgery; Adolescent; Adult; Age; Antigens; Biomarkers; Biopsy; Cancer; Cancer therapies; Carcinoma, Ovarian Epithelial; Care and treatment; Chemotherapy; Cohort Studies; Complications and side effects; Diagnosis; Disease-Free Survival; Endometriosis; Epithelial ovarian cancer; Excision (Surgery); Female; Fertility; Fertility Preservation - adverse effects; Fertility Preservation - methods; Fertility-sparing surgery; Follow-Up Studies; Gynecology; Health aspects; Health risk assessment; Health risks; Histology; Humans; Hysterectomy - adverse effects; Hysterectomy - methods; Kaplan-Meier Estimate; Lymph Node Excision; Medical prognosis; Methods; Multivariate analysis; Neoplasm Staging; Neoplasms, Glandular and Epithelial - mortality; Neoplasms, Glandular and Epithelial - pathology; Neoplasms, Glandular and Epithelial - surgery; Obstetrics; Organ Sparing Treatments - adverse effects; Organ Sparing Treatments - methods; Ovarian cancer; Ovarian Neoplasms - mortality; Ovarian Neoplasms - pathology; Ovarian Neoplasms - surgery; Ovariectomy - adverse effects; Ovariectomy - methods; Patients; Peritoneum - surgery; Pregnancy; Prognosis; Quality; Regression analysis; Reproductive age; Retrospective Studies; Risk factors; Risk groups; Stage I; Surgery; Survival; Treatment Outcome; Tumors; Womens health; Young Adult
• ISSN: 1477-7819; 1477-7819
• DOI: 10.1186/s12957-017-1222-4

Fertility-sparing surgery is indicated for patients with stage I epithelial ovarian cancers. We sought to evaluate the clinical outcomes and oncofertility in a cohort of patients of reproductive age with stage I epithelial ovarian cancer (EOC). Overall, 108 patients of reproductive age (≤ 40 years) diagnosed with stage I EOC who were treated at Peking Union Medical College Hospital between 1999 and 2013 were included in the study. The Kaplan-Meier model and Cox regression analyses were used for the survival analysis. The type of surgery included fertility-sparing surgery (FSS) (48.1%) and radical surgery (RS) (51.9%). After a median follow-up of 83 months, we observed that grade 3 or clear-cell carcinoma was the only independent risk factor for disease-free survival and tumor-specific survival in the multivariate analysis. Patients with grade 3 or clear-cell carcinoma tended to be older than 30 years, have endometriosis, and undergo RS (p