Simultaneous occurrence of splenic diffuse large B cell lymphoma and gastrointestinal stromal tumor in the stomach: a case report

• Published in: Diagnostic pathology 2018-08, Vol.13 (1), p.61-61, Article 61
• Main Authors: Chang, Jing, Chen, Qing, Jian, Yuan, Wei, Ping, Yang, Guang-Zhong, Wang, Ying, Fang, Xiang-Yang, Sun, Qian-Mei
• Format: Article
• Language: English
• Subjects: Abdomen; Aged; Aged patients; B-cell lymphoma; Biomarkers, Tumor - analysis; Biopsy; Blood tests; Body temperature; Cancer; Case Report; Case reports; Computed tomography; Diagnosis; Diffuse large B-cell lymphoma; Enlargement; Fever; Gastrointestinal cancer; Gastrointestinal stromal tumor; Gastrointestinal Stromal Tumors - chemistry; Gastrointestinal Stromal Tumors - diagnostic imaging; Gastrointestinal Stromal Tumors - pathology; Gastrointestinal tumors; Health aspects; Hepatitis; Hospitals; Humans; Immunoglobulins; Immunohistochemistry; Internal medicine; Lymph nodes; Lymphatic system; Lymphocytes B; Lymphocytic leukemia; Lymphoma; Lymphoma, Large B-Cell, Diffuse - chemistry; Lymphoma, Large B-Cell, Diffuse - diagnostic imaging; Lymphoma, Large B-Cell, Diffuse - pathology; Lymphoma, Large B-Cell, Diffuse - surgery; Malignancy; Neoplasms, Multiple Primary - chemistry; Neoplasms, Multiple Primary - diagnostic imaging; Neoplasms, Multiple Primary - pathology; Neoplasms, Multiple Primary - surgery; Neutrophils; Pathology; Patients; Positron Emission Tomography Computed Tomography; Spleen; Splenectomy; Splenic Neoplasms - chemistry; Splenic Neoplasms - diagnostic imaging; Splenic Neoplasms - pathology; Splenic Neoplasms - surgery; Stomach; Stomach Neoplasms - chemistry; Stomach Neoplasms - diagnostic imaging; Stomach Neoplasms - pathology; Tumors; Urogenital system
• ISSN: 1746-1596; 1746-1596
• DOI: 10.1186/s13000-018-0741-9

Although the primary malignant spleen tumor is relatively rare, lymphoma is the most common splenic malignancy. It can have quite different clinical manifestations that usually lead to relatively poor outcomes, and thus early and accurate diagnosis are of utmost importance. The present study reports a case of a 67-year-old female with high fever, abnormal spleen (diagnosed by PET/CT) and no obvious lymph node enlargement. After being subjected to splenectomy, the patient was diagnosed with splenic diffuse large B cell lymphoma coexisting with gastrointestinal stromal tumor in the stomach. To our knowledge, splenic lymphoma accompanied by gastrointestinal stromal tumor in the stomach is rarely reported. This case report discusses the diagnosis and case management of a patient referring to the existing literature.