Heterotopia of salivary gland tissue in the pancreas

Heterotopia of the salivary gland occurs mainly in the head and neck region of the human body, rarely in regions such as the rectum, but has never been demonstrated in the pancreas. Within a screening effort of pancreatic samples for detecting ΔNp63 expression, we discovered two pancreatic samples f...

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Bibliographic Details
Published in:Diagnostic pathology 2023-08, Vol.18 (1), p.1-98, Article 98
Main Authors: Martens, Sandrina, Coolens, Katarina, Olsen, Catharina, Lefesvre, Pierre, Rooman, Ilse
Format: Article
Language:English
Subjects:
Antibodies
Antigens
Basal cells
Calponin
Case Report
Cloning
Connective tissue
Ectopia
Ethics
Exocrine glands
Glial fibrillary acidic protein
Heterotopia
Histology
Islets of Langerhans
Mucin
Mucins
Pancreas
Salivary gland
Salivary glands
Staining
Submandibular gland
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Summary:Heterotopia of the salivary gland occurs mainly in the head and neck region of the human body, rarely in regions such as the rectum, but has never been demonstrated in the pancreas. Within a screening effort of pancreatic samples for detecting ΔNp63 expression, we discovered two pancreatic samples from a 35-year-old male showing salivary gland heterotopia. Immunohistochemical stainings were done for markers of healthy and neoplastic salivary glands and showed expression of calponin, CD142 and KRT14 but not of S100p, GFAP or CD117. A PAS-staining and Alcian Blue staining showed the presence of acid mucins. These staining patterns were consistent with non-neoplastic submandibular gland tissue comprised of abundant seromucous glands, basal cells and myoepithelial cells, all features typically absent in the pancreas. Also, no pancreatic islets of Langerhans were detected. We show for the first time that salivary gland heterotopia can occur at the location of the pancreas.
ISSN:1746-1596
1746-1596
DOI:10.1186/s13000-023-01385-x