Anticancer Activity and Underlying Mechanism of Phytochemicals against Multiple Myeloma

Multiple myeloma (MM)-a common hematologic malignancy of plasma cells-accounts for substantial mortality and morbidity rates. Due to the advent of novel therapies such as immunomodulatory drugs (IMiDs), proteasome inhibitors (PIs), and monoclonal antibodies (mAbs), response rates were increased and...

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Bibliographic Details
Published in:International journal of molecular sciences 2019-05, Vol.20 (9), p.2302
Main Authors: Kang, Beomku, Park, Hyunmin, Kim, Bonglee
Format: Article
Language:English
Subjects:
angiogenesis
Animals
anticancer
Antineoplastic Agents, Phytogenic - pharmacology
Antineoplastic Agents, Phytogenic - therapeutic use
Antitumor activity
Apoptosis
Apoptosis - drug effects
Autografts
Bortezomib
Cancer
CD95 antigen
Cell cycle
Cell Cycle Checkpoints - drug effects
Cell surface
Clinical trials
Corticosteroids
Cyclin-dependent kinases
Cytokines
Drug development
Drug therapy
Homeostasis
Humans
Immunosuppressive agents
Kinases
Ligands
Medical research
miRNA
Multiple myeloma
Multiple Myeloma - drug therapy
Multiple Myeloma - pathology
Natural products
Neovascularization, Pathologic - drug therapy
Phytochemicals
Phytochemicals - pharmacology
Phytochemicals - therapeutic use
Polyphenols
Protein biosynthesis
Protein synthesis
Proteins
Radiation therapy
Review
Stem cells
Transplantation
Tumor necrosis factor-TNF
Tumors
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Summary:Multiple myeloma (MM)-a common hematologic malignancy of plasma cells-accounts for substantial mortality and morbidity rates. Due to the advent of novel therapies such as immunomodulatory drugs (IMiDs), proteasome inhibitors (PIs), and monoclonal antibodies (mAbs), response rates were increased and free survival and overall survival have been elevated. However, adverse events including toxicity, neuropathy or continuous relapse are still problems. Thus, development of novel drugs which have less side effects and more effective is needed. This review aims to recapitulate the pharmacologic anti-MM mechanisms of various phytochemicals, elucidating their molecular targets. Keywords related to MM and natural products were searched in PUBMED/MEDLINE. Phytochemicals have been reported to display a variety of anti-MM activities, including apoptosis, cell cycle arrest, antiangiogenesis, and miRNA modulation. Some phytochemicals sensitize the conventional therapies such as dexamethasone. Also, there are clinical trials with phytochemicals such as agaricus, curcumin, and Neovastat regarding MM treatment. Taken together, this review elucidated and categorized the evidences that natural products and their bioactive compounds could be potent drugs in treating MM.
ISSN:1422-0067
1661-6596
1422-0067
DOI:10.3390/ijms20092302