The growth and shape of the eyeball and crystalline lens in utero documented by fetal MR imaging

To study the growth model, shape, and developmental relationship of lens and eyeball, we used two-dimensional Magnetic Resonance (MR) imaging to investigate gestationally age-related changes in the selected ocular parameters in vivo. We retrospectively reviewed the MR images from 126 fetuses ranging...

Full description

Saved in:
Bibliographic Details
Published in:Heliyon 2023-01, Vol.9 (1), p.e12885-e12885, Article e12885
Main Authors: Hong, Yingying, Ning, Li, Sun, Yang, Qian, Huijun, Ji, Yinghong
Format: Article
Language:English
Subjects:
Eye biometry
Fetus
Lens growth
Lens shape
MR imaging
Ocular globe growth
Citations: Items that this one cites
Items that cite this one
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
cited_by cdi_FETCH-LOGICAL-c533t-9610883caea3839e9857579f2133d0f0f46502b394fd6df875b6b5aae4fbcfc3
cites cdi_FETCH-LOGICAL-c533t-9610883caea3839e9857579f2133d0f0f46502b394fd6df875b6b5aae4fbcfc3
container_end_page e12885
container_issue 1
container_start_page e12885
container_title Heliyon
container_volume 9
creator Hong, Yingying
Ning, Li
Sun, Yang
Qian, Huijun
Ji, Yinghong
description To study the growth model, shape, and developmental relationship of lens and eyeball, we used two-dimensional Magnetic Resonance (MR) imaging to investigate gestationally age-related changes in the selected ocular parameters in vivo. We retrospectively reviewed the MR images from 126 fetuses ranging from 21 to 39 weeks' gestation. Ocular parameters on MR imaging of transverse plane were measured including lens diameter (LD), anteroposterior lens diameter (APLD), lens surface area (LS), globe diameter (GD), anteroposterior globe diameter (APGD), globe surface area (GS). The growth model of each biometric against gestational age (GA), aspect ratio of lens and globe (LD/APLD and GD/APGD), and growing relationship between the ratio of lens and globe surface area (LS/GS) were studied by statistical analysis. The growth model of most biometry for gestational age is logarithmic, except for the diameter of the ocular globe (GD and APGD) showing a quadratic growth pattern. Our study showed that the lens was consistently larger in the transverse than the anteroposterior diameters during 21–39 weeks(P 
doi_str_mv 10.1016/j.heliyon.2023.e12885
format article
fullrecord <record><control><sourceid>proquest_doaj_</sourceid><recordid>TN_cdi_doaj_primary_oai_doaj_org_article_7dc5e8eebea045b2bf130a23179298ad</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><els_id>S2405844023000920</els_id><doaj_id>oai_doaj_org_article_7dc5e8eebea045b2bf130a23179298ad</doaj_id><sourcerecordid>2768816071</sourcerecordid><originalsourceid>FETCH-LOGICAL-c533t-9610883caea3839e9857579f2133d0f0f46502b394fd6df875b6b5aae4fbcfc3</originalsourceid><addsrcrecordid>eNqFUctu1DAUjRCIVqWfAPKSzQx-xImzAaGKR6UiJDR748d14lHGHuykVf4etxmqdsXK9r3nnnN8T1W9JXhLMGk-7LcDjH6JYUsxZVsgVAj-ojqnNeYbUdf45ZP7WXWZ8x5jTLhoupa9rs5Y0wheU3Fe_d4NgPoU76YBqWBRHtQRUHRoKnVYQKtxfGiYtOSpPHwANELIyAc0T5AistHMBwgTWKQX5KCg0I9fyB9U70P_pnrl1Jjh8nReVLuvX3ZX3zc3P79dX32-2RjO2LTpGoKFYEaBYoJ10Ane8rZzlDBmscOubjimmnW1s411ouW60VwpqJ02zrCL6nqltVHt5TEV9bTIqLx8KMTUS5Umb0aQrTUcBIAGhWuuqXaEYUUZaTvaCWUL18eV6zjrA1hT_pbU-Iz0eSf4QfbxVhbTpDgrBO9PBCn-mSFP8uCzgXFUAeKcJW0bIUiDW1KgfIWaFHNO4B5lCJb3Wcu9PGUt77OWa9Zl7t1Tj49T_5ItgE8rAMrSbz0kmY2HYMD6BGYqa_H_kfgLEc2_Ng</addsrcrecordid><sourcetype>Open Website</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>2768816071</pqid></control><display><type>article</type><title>The growth and shape of the eyeball and crystalline lens in utero documented by fetal MR imaging</title><source>PubMed (Medline)</source><source>ScienceDirect Journals</source><creator>Hong, Yingying ; Ning, Li ; Sun, Yang ; Qian, Huijun ; Ji, Yinghong</creator><creatorcontrib>Hong, Yingying ; Ning, Li ; Sun, Yang ; Qian, Huijun ; Ji, Yinghong</creatorcontrib><description>To study the growth model, shape, and developmental relationship of lens and eyeball, we used two-dimensional Magnetic Resonance (MR) imaging to investigate gestationally age-related changes in the selected ocular parameters in vivo. We retrospectively reviewed the MR images from 126 fetuses ranging from 21 to 39 weeks' gestation. Ocular parameters on MR imaging of transverse plane were measured including lens diameter (LD), anteroposterior lens diameter (APLD), lens surface area (LS), globe diameter (GD), anteroposterior globe diameter (APGD), globe surface area (GS). The growth model of each biometric against gestational age (GA), aspect ratio of lens and globe (LD/APLD and GD/APGD), and growing relationship between the ratio of lens and globe surface area (LS/GS) were studied by statistical analysis. The growth model of most biometry for gestational age is logarithmic, except for the diameter of the ocular globe (GD and APGD) showing a quadratic growth pattern. Our study showed that the lens was consistently larger in the transverse than the anteroposterior diameters during 21–39 weeks(P &lt; 0.001). Besides, the ratio of surface area (LS/GS) was not significantly changing with GA(P = 0.4908), while the increase of LS was significantly accorded with that of GS(P &lt; 0.001). The lens shape throughout fetal life may take part in the process, shape changing from vertical ellipsoid, spherical to transversal ellipsoid, based on the logarithmically increased ratio of lens transverse and anteroposterior diameters. In the meanwhile, the aspect ratio of eyeball in late fetal life may imply a gradually spherical shape during gestation. Nomogram data from this study may provide appropriate information about morphological changes in the fetal lens and the synchronous relationship between lens and eyeball.</description><identifier>ISSN: 2405-8440</identifier><identifier>EISSN: 2405-8440</identifier><identifier>DOI: 10.1016/j.heliyon.2023.e12885</identifier><identifier>PMID: 36685428</identifier><language>eng</language><publisher>England: Elsevier Ltd</publisher><subject>Eye biometry ; Fetus ; Lens growth ; Lens shape ; MR imaging ; Ocular globe growth</subject><ispartof>Heliyon, 2023-01, Vol.9 (1), p.e12885-e12885, Article e12885</ispartof><rights>2023 The Authors</rights><rights>2023 The Authors.</rights><rights>2023 The Authors 2023</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c533t-9610883caea3839e9857579f2133d0f0f46502b394fd6df875b6b5aae4fbcfc3</citedby><cites>FETCH-LOGICAL-c533t-9610883caea3839e9857579f2133d0f0f46502b394fd6df875b6b5aae4fbcfc3</cites><orcidid>0000-0003-3340-5373</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC9851875/pdf/$$EPDF$$P50$$Gpubmedcentral$$Hfree_for_read</linktopdf><linktohtml>$$Uhttps://www.sciencedirect.com/science/article/pii/S2405844023000920$$EHTML$$P50$$Gelsevier$$Hfree_for_read</linktohtml><link.rule.ids>230,314,727,780,784,885,3549,27924,27925,45780,53791,53793</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/36685428$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Hong, Yingying</creatorcontrib><creatorcontrib>Ning, Li</creatorcontrib><creatorcontrib>Sun, Yang</creatorcontrib><creatorcontrib>Qian, Huijun</creatorcontrib><creatorcontrib>Ji, Yinghong</creatorcontrib><title>The growth and shape of the eyeball and crystalline lens in utero documented by fetal MR imaging</title><title>Heliyon</title><addtitle>Heliyon</addtitle><description>To study the growth model, shape, and developmental relationship of lens and eyeball, we used two-dimensional Magnetic Resonance (MR) imaging to investigate gestationally age-related changes in the selected ocular parameters in vivo. We retrospectively reviewed the MR images from 126 fetuses ranging from 21 to 39 weeks' gestation. Ocular parameters on MR imaging of transverse plane were measured including lens diameter (LD), anteroposterior lens diameter (APLD), lens surface area (LS), globe diameter (GD), anteroposterior globe diameter (APGD), globe surface area (GS). The growth model of each biometric against gestational age (GA), aspect ratio of lens and globe (LD/APLD and GD/APGD), and growing relationship between the ratio of lens and globe surface area (LS/GS) were studied by statistical analysis. The growth model of most biometry for gestational age is logarithmic, except for the diameter of the ocular globe (GD and APGD) showing a quadratic growth pattern. Our study showed that the lens was consistently larger in the transverse than the anteroposterior diameters during 21–39 weeks(P &lt; 0.001). Besides, the ratio of surface area (LS/GS) was not significantly changing with GA(P = 0.4908), while the increase of LS was significantly accorded with that of GS(P &lt; 0.001). The lens shape throughout fetal life may take part in the process, shape changing from vertical ellipsoid, spherical to transversal ellipsoid, based on the logarithmically increased ratio of lens transverse and anteroposterior diameters. In the meanwhile, the aspect ratio of eyeball in late fetal life may imply a gradually spherical shape during gestation. Nomogram data from this study may provide appropriate information about morphological changes in the fetal lens and the synchronous relationship between lens and eyeball.</description><subject>Eye biometry</subject><subject>Fetus</subject><subject>Lens growth</subject><subject>Lens shape</subject><subject>MR imaging</subject><subject>Ocular globe growth</subject><issn>2405-8440</issn><issn>2405-8440</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2023</creationdate><recordtype>article</recordtype><sourceid>DOA</sourceid><recordid>eNqFUctu1DAUjRCIVqWfAPKSzQx-xImzAaGKR6UiJDR748d14lHGHuykVf4etxmqdsXK9r3nnnN8T1W9JXhLMGk-7LcDjH6JYUsxZVsgVAj-ojqnNeYbUdf45ZP7WXWZ8x5jTLhoupa9rs5Y0wheU3Fe_d4NgPoU76YBqWBRHtQRUHRoKnVYQKtxfGiYtOSpPHwANELIyAc0T5AistHMBwgTWKQX5KCg0I9fyB9U70P_pnrl1Jjh8nReVLuvX3ZX3zc3P79dX32-2RjO2LTpGoKFYEaBYoJ10Ane8rZzlDBmscOubjimmnW1s411ouW60VwpqJ02zrCL6nqltVHt5TEV9bTIqLx8KMTUS5Umb0aQrTUcBIAGhWuuqXaEYUUZaTvaCWUL18eV6zjrA1hT_pbU-Iz0eSf4QfbxVhbTpDgrBO9PBCn-mSFP8uCzgXFUAeKcJW0bIUiDW1KgfIWaFHNO4B5lCJb3Wcu9PGUt77OWa9Zl7t1Tj49T_5ItgE8rAMrSbz0kmY2HYMD6BGYqa_H_kfgLEc2_Ng</recordid><startdate>20230101</startdate><enddate>20230101</enddate><creator>Hong, Yingying</creator><creator>Ning, Li</creator><creator>Sun, Yang</creator><creator>Qian, Huijun</creator><creator>Ji, Yinghong</creator><general>Elsevier Ltd</general><general>Elsevier</general><scope>6I.</scope><scope>AAFTH</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope><scope>5PM</scope><scope>DOA</scope><orcidid>https://orcid.org/0000-0003-3340-5373</orcidid></search><sort><creationdate>20230101</creationdate><title>The growth and shape of the eyeball and crystalline lens in utero documented by fetal MR imaging</title><author>Hong, Yingying ; Ning, Li ; Sun, Yang ; Qian, Huijun ; Ji, Yinghong</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c533t-9610883caea3839e9857579f2133d0f0f46502b394fd6df875b6b5aae4fbcfc3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2023</creationdate><topic>Eye biometry</topic><topic>Fetus</topic><topic>Lens growth</topic><topic>Lens shape</topic><topic>MR imaging</topic><topic>Ocular globe growth</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Hong, Yingying</creatorcontrib><creatorcontrib>Ning, Li</creatorcontrib><creatorcontrib>Sun, Yang</creatorcontrib><creatorcontrib>Qian, Huijun</creatorcontrib><creatorcontrib>Ji, Yinghong</creatorcontrib><collection>ScienceDirect Open Access Titles</collection><collection>Elsevier:ScienceDirect:Open Access</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><collection>PubMed Central (Full Participant titles)</collection><collection>DOAJ Directory of Open Access Journals</collection><jtitle>Heliyon</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Hong, Yingying</au><au>Ning, Li</au><au>Sun, Yang</au><au>Qian, Huijun</au><au>Ji, Yinghong</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>The growth and shape of the eyeball and crystalline lens in utero documented by fetal MR imaging</atitle><jtitle>Heliyon</jtitle><addtitle>Heliyon</addtitle><date>2023-01-01</date><risdate>2023</risdate><volume>9</volume><issue>1</issue><spage>e12885</spage><epage>e12885</epage><pages>e12885-e12885</pages><artnum>e12885</artnum><issn>2405-8440</issn><eissn>2405-8440</eissn><abstract>To study the growth model, shape, and developmental relationship of lens and eyeball, we used two-dimensional Magnetic Resonance (MR) imaging to investigate gestationally age-related changes in the selected ocular parameters in vivo. We retrospectively reviewed the MR images from 126 fetuses ranging from 21 to 39 weeks' gestation. Ocular parameters on MR imaging of transverse plane were measured including lens diameter (LD), anteroposterior lens diameter (APLD), lens surface area (LS), globe diameter (GD), anteroposterior globe diameter (APGD), globe surface area (GS). The growth model of each biometric against gestational age (GA), aspect ratio of lens and globe (LD/APLD and GD/APGD), and growing relationship between the ratio of lens and globe surface area (LS/GS) were studied by statistical analysis. The growth model of most biometry for gestational age is logarithmic, except for the diameter of the ocular globe (GD and APGD) showing a quadratic growth pattern. Our study showed that the lens was consistently larger in the transverse than the anteroposterior diameters during 21–39 weeks(P &lt; 0.001). Besides, the ratio of surface area (LS/GS) was not significantly changing with GA(P = 0.4908), while the increase of LS was significantly accorded with that of GS(P &lt; 0.001). The lens shape throughout fetal life may take part in the process, shape changing from vertical ellipsoid, spherical to transversal ellipsoid, based on the logarithmically increased ratio of lens transverse and anteroposterior diameters. In the meanwhile, the aspect ratio of eyeball in late fetal life may imply a gradually spherical shape during gestation. Nomogram data from this study may provide appropriate information about morphological changes in the fetal lens and the synchronous relationship between lens and eyeball.</abstract><cop>England</cop><pub>Elsevier Ltd</pub><pmid>36685428</pmid><doi>10.1016/j.heliyon.2023.e12885</doi><orcidid>https://orcid.org/0000-0003-3340-5373</orcidid><oa>free_for_read</oa></addata></record>
fulltext fulltext
identifier ISSN: 2405-8440
ispartof Heliyon, 2023-01, Vol.9 (1), p.e12885-e12885, Article e12885
issn 2405-8440
2405-8440
language eng
recordid cdi_doaj_primary_oai_doaj_org_article_7dc5e8eebea045b2bf130a23179298ad
source PubMed (Medline); ScienceDirect Journals
subjects Eye biometry
Fetus
Lens growth
Lens shape
MR imaging
Ocular globe growth
title The growth and shape of the eyeball and crystalline lens in utero documented by fetal MR imaging
url http://sfxeu10.hosted.exlibrisgroup.com/loughborough?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2025-01-01T12%3A43%3A19IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-proquest_doaj_&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=The%20growth%20and%20shape%20of%20the%20eyeball%20and%20crystalline%20lens%20in%20utero%20documented%20by%20fetal%20MR%20imaging&rft.jtitle=Heliyon&rft.au=Hong,%20Yingying&rft.date=2023-01-01&rft.volume=9&rft.issue=1&rft.spage=e12885&rft.epage=e12885&rft.pages=e12885-e12885&rft.artnum=e12885&rft.issn=2405-8440&rft.eissn=2405-8440&rft_id=info:doi/10.1016/j.heliyon.2023.e12885&rft_dat=%3Cproquest_doaj_%3E2768816071%3C/proquest_doaj_%3E%3Cgrp_id%3Ecdi_FETCH-LOGICAL-c533t-9610883caea3839e9857579f2133d0f0f46502b394fd6df875b6b5aae4fbcfc3%3C/grp_id%3E%3Coa%3E%3C/oa%3E%3Curl%3E%3C/url%3E&rft_id=info:oai/&rft_pqid=2768816071&rft_id=info:pmid/36685428&rfr_iscdi=true