Generation of a human induced pluripotent stem cell line from a familial Alzheimer's disease PSEN1 T119I patient

Human induced pluripotent stem cells (hiPSC) line FLENIi001-A was reprogrammed from dermal fibroblasts using the lentiviral-hSTEMCCA-loxP vector. Fibroblasts were obtained from a skin biopsy of a 72-year-old Caucasian male familial Alzheimer's disease patient carrying the T119I mutation in the...

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Published in:Stem cell research 2021-05, Vol.53, p.102325-102325, Article 102325
Main Authors: Isaja, Luciana, Rodríguez-Varela, María Soledad, Marazita, Mariela, Mucci, Sofía, Itzcovich, Tatiana, Chrem-Méndez, Patricio, Niikado, Matías, Ferriol-Laffouillere, Sofía Luján, Allegri, Ricardo, Martinetto, Horacio, Sevlever, Gustavo Emilio, Scassa, María Elida, Surace, Ezequiel Ignacio, Romorini, Leonardo
Format: Article
Language:English
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Summary:Human induced pluripotent stem cells (hiPSC) line FLENIi001-A was reprogrammed from dermal fibroblasts using the lentiviral-hSTEMCCA-loxP vector. Fibroblasts were obtained from a skin biopsy of a 72-year-old Caucasian male familial Alzheimer's disease patient carrying the T119I mutation in the PSEN1 gene. PSEN1 genotype was maintained and stemness and pluripotency confirmed in the FLENIi001-A hiPSC line.
ISSN:1873-5061
1876-7753
DOI:10.1016/j.scr.2021.102325