Atropine is more efficient than ZM241385 to reduce a drastic level of fade caused by cisatracurium at 50 Hz

The effects of atropine (non selective muscarinic antagonist) and ZM241385 (A2A receptors antagonist) in the cisatracurium-induced drastic (100%) level of fade at 50 Hz (10 s) (100% Fade) were compared in the phrenic nerve-diaphragm muscle preparations of rats indirectly stimulated at a physiologica...

Full description

Saved in:
Bibliographic Details
Published in:Acta scientiarum. Health sciences 2016, Vol.38 (2), p.165
Main Authors: Pimentel, Arethusa Lobo, Prado, Gabriela De Castro, Alves-Do-Prado, Wilson, Ambiel, Célia Regina
Format: Article
Language:English
Subjects:
adenosine
muscarinic receptors
Muscular system
Nervous system
neuromuscular blocker
Pharmacology
Rodents
tetanic fade
train-of-four
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:The effects of atropine (non selective muscarinic antagonist) and ZM241385 (A2A receptors antagonist) in the cisatracurium-induced drastic (100%) level of fade at 50 Hz (10 s) (100% Fade) were compared in the phrenic nerve-diaphragm muscle preparations of rats indirectly stimulated at a physiological tetanic frequency (50 Hz). The lowest dose and the instant cisatracurium caused 100% Fade were investigated. Cisatracurium induced 100% Fade 15 min after being administered. Atropine reduced the cisatracurium-induced 100% Fade, but the administration of ZM241385 separately, or combined with atropine, did not cause any effect in the cisatracurium-induced 100% Fade. Data indicate that the simultaneous blockage of M1 and M2 muscarinic receptors on motor nerve terminal by atropine is more efficient than the blockage of presynaptic A2A receptors for a safer recovery of patients from neuromuscular blockade caused by cisatracurium.
ISSN:1679-9291
1807-8648
DOI:10.4025/actascihealthsci.v38i2.25418