Selenium-rich yeast attenuates ochratoxin A-induced small intestinal injury in broiler chickens by activating the Nrf2 pathway and inhibiting NF-KB activation

[Display omitted] •OTA induce small intestinal injury in broiler chickens.•Selenium-rich yeast attenuates Ochratoxin A toxicity.•The Nrf2 pathway and NF-KB pathway were involved in SeY protect OTA-induced toxicity. The aim was to investigate whether selenium-enriched yeast (SeY) can attenuate intest...

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Bibliographic Details
Published in:Journal of functional foods 2020-03, Vol.66 (C), p.103784, Article 103784
Main Authors: Tong, Cui, Li, Peng, Yu, Li-Hui, Li, Lin, Li, Kang, Chen, Yueli, Yang, Shu-Hua, Long, Miao
Format: Article
Language:English
Subjects:
Intestinal injury
NF-κB pathway
Nrf2 pathway
Ochratoxin A
Selenium-rich yeast
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Summary:[Display omitted] •OTA induce small intestinal injury in broiler chickens.•Selenium-rich yeast attenuates Ochratoxin A toxicity.•The Nrf2 pathway and NF-KB pathway were involved in SeY protect OTA-induced toxicity. The aim was to investigate whether selenium-enriched yeast (SeY) can attenuate intestinal injury in broiler chickens induced by ochratoxin A (OTA). Here, the results showed that SeY addition increased the body weight, feed conversion ratio, villi height, villus/crypt ratio, and the numbers of goblet cells. Furthermore, the levels of oxidative stress by SeY addition (superoxide dismutase activity, total antioxidant capacity, and total glutathione content) were significantly decreased (P 
ISSN:1756-4646
2214-9414
DOI:10.1016/j.jff.2020.103784