Evaluation of adenomyosis after gonadotrophin-releasing hormone agonist therapy using ultrasound post-processing imaging: a pilot study

Objective We explored a method for the quantitative sonographic analysis of myometrial texture using computer-aided image analysis software to assess outcomes following treatment with gonadotrophin-releasing hormone (GnRH) agonist for adenomyosis in women with infertility. Method Data for patients w...

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Bibliographic Details
Published in:Journal of international medical research 2020-06, Vol.48 (6), p.300060520920056-300060520920056
Main Authors: Chou, Szu-Yuan, Chan, Cindy, Lee, Yu-Chieh, Yu, Tzu-Ning, Tzeng, Chii-Ruey, Chen, Chi-Huang
Format: Article
Language:English
Subjects:
Adenomyosis - diagnostic imaging
Adenomyosis - physiopathology
Adult
CA-125 Antigen - analysis
Female
Gonadotropin-Releasing Hormone - agonists
Histograms
Hormone Replacement Therapy - methods
Hormones - therapeutic use
Humans
Image Processing, Computer-Assisted - methods
Leuprolide - pharmacology
Myometrium - diagnostic imaging
Pilot Projects
Retrospective Clinical Research Report
Retrospective Studies
Ultrasonic imaging
Ultrasonography - methods
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Summary:Objective We explored a method for the quantitative sonographic analysis of myometrial texture using computer-aided image analysis software to assess outcomes following treatment with gonadotrophin-releasing hormone (GnRH) agonist for adenomyosis in women with infertility. Method Data for patients with ultrasound images of the myometrium obtained at Taipei Medical University Hospital from 1 September 2018 to 5 April 5 2019 were analyzed. Only 10 patients with 20 ultrasound images matched the eligibility criteria. The images were divided into pre-treatment (n = 10) and post-treatment images (n = 10) and quantitative grayscale histograms were obtained from the ultrasound images using publicly available ImageJ computer-aided image analysis software. We analyzed the differences between the pre- and post-treatment images using the Mann–Whitney test and compared the results with outcomes assessed by serum CA-125 levels. Results Image analysis of the grayscale histograms revealed significant differences between before and after treatment. The classification of the myometrium pre-treatment and post-treatment was similar using CA-125 and histogram grayscale analysis. Conclusion Computer-aided image analysis of grayscale histograms of the myometrium obtained from ultrasound images is an alternative method for assessing myometrial conditions after GnRH agonist treatment in patients with adenomyosis.
ISSN:0300-0605
1473-2300
DOI:10.1177/0300060520920056