Chemical Composition and Chronic Toxicity of Disc-Cultured Antrodia cinnamomea Fruiting Bodies

Antrodia cinnamomea (AC) is a popular fungus for use as folk medicine in health maintenance and disease prevention and treatment. Disc culture is a novel technique for producing AC fruiting bodies. This study aimed to investigate the bioactive components and toxicological properties of disc-cultured...

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Bibliographic Details
Published in:Toxics (Basel) 2022-10, Vol.10 (10), p.587
Main Authors: Liu, Shou-Chou, Wu, Tung-Ying, Hsu, Tai-Hao, Lai, Ming-Nan, Wu, Yang-Chang, Ng, Lean-Teik
Format: Article
Language:English
Subjects:
Acids
Animals
Antrodia cinnamomea
bioactive triterpenoids
Biocompatibility
Biological activity
Body weight
Cancer
Chemical composition
Chronic illnesses
Chronic toxicity
disc culture
Distilled water
Food intake
Fruit bodies
fruiting bodies
Hematology
Laboratory animals
Liquid chromatography
Organs
Ovaries
Thymus gland
Toxicity
toxicological properties
Triterpenoids
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Summary:Antrodia cinnamomea (AC) is a popular fungus for use as folk medicine in health maintenance and disease prevention and treatment. Disc culture is a novel technique for producing AC fruiting bodies. This study aimed to investigate the bioactive components and toxicological properties of disc-cultured AC fruiting body powders (ACP) in rats. The HPLC technique was used to quantify the composition of bioactive triterpenoids in ACP. Toxicological properties were evaluated on male and female Sprague-Dawley rats receiving ACP orally at 200, 600, and 1000 mg/kg body weight for 90 days; the control group received only distilled water. The results show that ACP contained seven important AC index compounds, namely antcins A, B, C, K, and H, dehydrosulphurenic acid, and dehydroeburicoic acid. At the tested doses, oral ACP administration for 90 days caused no mortality, adverse effects on general health, body and organ weights, and food intake. Furthermore, no significant variations were observed in hematological and biochemical parameters among either sex of ACP-treated and control animals. An histopathological examination of vital organs showed no significant structural changes in organs, even in high-dose ACP-treated animals. This study indicated that ACP contained the major bioactive triterpenoids of AC fruiting bodies, and its no-observed-adverse-effect level (NOAEL) was 1000 mg/kg/day, about 20 times the recommended daily intake.
ISSN:2305-6304
2305-6304
DOI:10.3390/toxics10100587