Triton X-100 catalyzed synthesis of α-aminophosphonates

Synthesis of α-aminophosphonates by a three-component condensation of an aldehyde, amines and dialkyl phosphites in the presence of a non-ionic surfactant Triton X-100 catalyst at 70°C in aqueous medium is accomplished. The advantages are high yield, mild reaction conditions, simple work-up and eco-...

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Bibliographic Details
Published in:Arabian journal of chemistry 2016-09, Vol.9 (S1), p.S685-S690
Main Authors: Reddy, Nemallapudi Bakthavatchala, Sundar, Chereddy Syama, Rani, Chinthaparthi Radha, Rao, Kunda Uma Maheswara, Nayak, Sandip Kumar, Reddy, Cirandur Suresh
Format: Article
Language:English
Subjects:
Dialkylphosphites
Non-ionic surfactant catalyst
Triton X-100
α-Aminophosphonates
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Summary:Synthesis of α-aminophosphonates by a three-component condensation of an aldehyde, amines and dialkyl phosphites in the presence of a non-ionic surfactant Triton X-100 catalyst at 70°C in aqueous medium is accomplished. The advantages are high yield, mild reaction conditions, simple work-up and eco-friendliness. All the newly-synthesized compounds (4a–j) exhibited moderate in vitro antibacterial and antifungal activities.
ISSN:1878-5352
1878-5379
DOI:10.1016/j.arabjc.2011.07.025