RETRACTED ARTICLE: Exposure to pesticide components causes recurrent pregnancy loss by increasing placental oxidative stress and apoptosis: a case–control study

We investigated the plasma levels of pesticides components namely polychlorinated biphenyls (PCBs), dieldrin, dichlorodiphenyldichloroethylene (DDE), ethion, malathion, and chlorpyrifos in recurrent pregnancy loss (RPL) cases, and tested their associations with placental oxidative stress (OS) biomar...

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Bibliographic Details
Published in:Scientific reports 2023-06, Vol.13 (1), p.9147-9, Article 9147
Main Authors: El-Baz, Mona A. H., Amin, Ahmed F., Mohany, Khalid M.
Format: Article
Language:English
Subjects:
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Chlorpyrifos
DDE
Developing countries
Dieldrin
Gas chromatography
Humanities and Social Sciences
LDCs
Malathion
Mass spectrometry
multidisciplinary
Nitric oxide
Nitrous oxide
Oxidative stress
PCB
Pesticides
Polychlorinated biphenyls
Pregnancy
Risk factors
Science
Science (multidisciplinary)
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Summary:We investigated the plasma levels of pesticides components namely polychlorinated biphenyls (PCBs), dieldrin, dichlorodiphenyldichloroethylene (DDE), ethion, malathion, and chlorpyrifos in recurrent pregnancy loss (RPL) cases, and tested their associations with placental oxidative stress (OS) biomarkers [nitric oxide (NO . ), thiobarbituric acid reactive substances (TBARS), reduced glutathione (GSH), and superoxide dismutase (SOD)] and with placental apoptotic/antiapoptotic indices (Bcl-2 and caspase-3), and evaluated their possible cut-off points to distinguish RPL cases. The study recruited 101 pregnant women divided into; G1 [n = 49, control, normal 1st-trimester pregnancy, normal obstetric history with at least one previous normal live birth], G2 [n = 26, cases with missed abortion (
ISSN:2045-2322
2045-2322
DOI:10.1038/s41598-023-36363-2