Interactions Between Atrial Fibrillation and Natriuretic Peptide in Predicting Heart Failure Hospitalization or Cardiovascular Death

Background Natriuretic peptides are routinely quantified to diagnose heart failure (HF). Their concentrations are also elevated in atrial fibrillation (AF). To clarify their value in predicting future cardiovascular events, we measured natriuretic peptides in unselected patients with cardiovascular...

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Published in:Journal of the American Heart Association 2022-02, Vol.11 (4), p.e022833-e022833
Main Authors: Brady, Paul F, Chua, Winnie, Nehaj, Frantisek, Connolly, Derek L, Khashaba, Alya, Purmah, Yanish J V, Ul-Qamar, Muhammad J, Thomas, Mark R, Varma, Chetan, Schnabel, Renate B, Zeller, Tanja, Fabritz, Larissa, Kirchhof, Paulus F
Format: Article
Language:English
Subjects:
atrial fibrillation
Atrial Fibrillation - complications
Atrial Fibrillation - diagnosis
Biomarkers
cardiovascular death
cohort study
Echocardiography
Female
heart failure
Heart Failure - diagnosis
Hospitalization
Humans
Male
Natriuretic Peptide, Brain
N‐terminal pro‐B‐type natriuretic peptide
Original Research
Peptide Fragments
Prognosis
Vasodilator Agents
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Summary:Background Natriuretic peptides are routinely quantified to diagnose heart failure (HF). Their concentrations are also elevated in atrial fibrillation (AF). To clarify their value in predicting future cardiovascular events, we measured natriuretic peptides in unselected patients with cardiovascular conditions and related their concentrations to AF and HF status and outcomes. Methods and Results Consecutive patients with cardiovascular conditions presenting to a large teaching hospital underwent clinical assessment, 7-day ECG monitoring, and echocardiography to diagnose AF and HF. NT-proBNP (N-terminal pro-B-type natriuretic peptide) was centrally quantified. Based on a literature review, four NT-proBNP groups were defined (
ISSN:2047-9980
2047-9980
DOI:10.1161/jaha.121.022833