Nardostachys jatamansi and levodopa combination alleviates Parkinson's disease symptoms in rats through activation of Nrf2 and inhibition of NLRP3 signaling pathways

Levodopa combined with traditional Chinese medicine has a synergistic effect on Parkinson's disease (PD). Recently, we demonstrated that (D. Don) DC. [syn. D.Don, DC.] (Valerianaceae) (NJ) can alleviate PD. To explore the synergistic effect of NJ combined with levodopa against PD. The PD model...

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Bibliographic Details
Published in:Pharmaceutical biology 2023-12, Vol.61 (1), p.1175-1185
Main Authors: Li, Jiayuan, Yu, Jiahe, Guo, Jianyou, Liu, Jinfeng, Wan, Guohui, Wei, Xiaojia, Yang, Xue, Shi, Jinli
Format: Article
Language:English
Subjects:
Animals
Antioxidants
Chinese medicine
Cytokines
Dopamine
dopaminergic neurons
Drugs, Chinese Herbal - pharmacology
Dyskinesia
Ethanol
Levodopa
Levodopa - pharmacology
Lipid peroxidation
molecular docking
Movement disorders
nardosinone
Nardostachys - chemistry
Nardostachys jatamansi
Neurodegenerative diseases
neurotransmitters
NF-E2-Related Factor 2 - metabolism
NLR Family, Pyrin Domain-Containing 3 Protein
Oxidative stress
Parkinson Disease - drug therapy
Parkinson's disease
Pharmacodynamics
Pyrin protein
Rats
Rats, Sprague-Dawley
Rotenone
Signal Transduction
Traditional Chinese medicine
Tumor necrosis factor-TNF
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Summary:Levodopa combined with traditional Chinese medicine has a synergistic effect on Parkinson's disease (PD). Recently, we demonstrated that (D. Don) DC. [syn. D.Don, DC.] (Valerianaceae) (NJ) can alleviate PD. To explore the synergistic effect of NJ combined with levodopa against PD. The PD model was established by injecting rotenone. Eighty-four Sprague-Dawley rats were randomly divided into seven groups: sham, model, different doses of NJ (0.31, 0.62, or 1.24 g/kg) combined with levodopa (25 mg/kg), and levodopa alone (25 and 50 mg/kg) groups. The synergistic effect of the combination was investigated by pharmacodynamic investigation and detection of expression of nuclear factor erythro2-related factor 2 (Nrf2) and NLR family proteins containing Pyrin-related domain 3 (NLRP3) pathways. Compared with the model group, NJ + levodopa (1.24 g/kg + 25 mg/kg) increased the moving distance of PD rats in the open field (2395.34 ± 668.73 vs. 1501.41 ± 870.23,  
ISSN:1388-0209
1744-5116
DOI:10.1080/13880209.2023.2244176