Patients’ Educational Program Could Improve Azathioprine Adherence in Crohn’s Disease Maintenance Therapy

Aim. To determine the risk factors of nonadherence to azathioprine (AZA) maintenance therapy for Crohn’s disease (CD) and to evaluate the influence of patients’ educational program on adherence to AZA maintenance therapy. Methods. Patients receiving AZA as maintenance therapy for CD were enrolled. D...

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Bibliographic Details
Published in:Gastroenterology research and practice 2020, Vol.2020 (2020), p.1-7
Main Authors: Zhong, Jie, Zhang, Tianyu, Hong, Liwen, Zhang, Chen, Fan, Rong, Wang, Lei, Wang, Zhengting
Format: Article
Language:English
Subjects:
Age
Alcoholism
Anxiety
Azathioprine
Care and treatment
Education
Endoscopy
Family income
Inflammatory bowel disease
Knowledge
Multivariate analysis
Patient compliance
Patient education
Questionnaires
Risk factors
Statistical analysis
Study and teaching
Surgery
Surveillance
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Summary:Aim. To determine the risk factors of nonadherence to azathioprine (AZA) maintenance therapy for Crohn’s disease (CD) and to evaluate the influence of patients’ educational program on adherence to AZA maintenance therapy. Methods. Patients receiving AZA as maintenance therapy for CD were enrolled. Demographic data, clinical data, and usage information were collected. Univariate and multivariate analyses were performed to identify the risk factors of nonadherence. Then, patients’ educational program was conducted. One year after the program, the improvements in adherence and relapse rates were compared between educational and noneducational groups. Results. A total of 378 CD patients receiving AZA as maintenance therapy were enrolled from September 2008 to September 2018. Nonadherence occurred in 43.9% (166/378) of patients. Univariate analysis revealed that young age, education, alcoholism, anxiety, depression, concern belief, and lack of necessity belief and AZA knowledge were risk factors of nonadherence (P
ISSN:1687-6121
1687-630X
DOI:10.1155/2020/6848293