5-Fluorouracil: A Narrative Review on the Role of Regulatory Mechanisms in Driving Resistance to This Chemotherapeutic Agent

5-fluorouracil (5-FU) is among the mostly administrated chemotherapeutic agents for a wide variety of neoplasms. Non-coding RNAs have a central impact on the determination of the response of patients to 5-FU. These transcripts via modulation of cancer-related pathways, cell apoptosis, autophagy, epi...

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Bibliographic Details
Published in:Frontiers in oncology 2021-04, Vol.11, p.658636-658636
Main Authors: Ghafouri-Fard, Soudeh, Abak, Atefe, Tondro Anamag, Farhad, Shoorei, Hamed, Fattahi, Faranak, Javadinia, Seyed Alireza, Basiri, Abbas, Taheri, Mohammad
Format: Article
Language:English
Subjects:
biomarker
expression
fluorouracil
lncRNA
miRNA
Oncology
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Summary:5-fluorouracil (5-FU) is among the mostly administrated chemotherapeutic agents for a wide variety of neoplasms. Non-coding RNAs have a central impact on the determination of the response of patients to 5-FU. These transcripts via modulation of cancer-related pathways, cell apoptosis, autophagy, epithelial-mesenchymal transition, and other aspects of cell behavior can affect cell response to 5-FU. Modulation of expression levels of microRNAs or long non-coding RNAs may be a suitable approach to sensitize tumor cells to 5-FU treatment via modulating multiple biological signaling pathways such as Hippo/YAP, Wnt/β-catenin, Hedgehog, NF-kB, and Notch cascades. Moreover, there is an increasing interest in targeting these transcripts in various kinds of cancers that are treated by 5-FU. In the present article, we provide a review of the function of non-coding transcripts in the modulation of response of neoplastic cells to 5-FU.
ISSN:2234-943X
2234-943X
DOI:10.3389/fonc.2021.658636