Zinc is a master-regulator of sperm function associated with binding, motility, and metabolic modulation during porcine sperm capacitation

Sperm capacitation is a post-testicular maturation step endowing spermatozoa with fertilizing capacity within the female reproductive tract, significant for fertility, reproductive health, and contraception. Recently discovered mammalian sperm zinc signatures and their changes during sperm in vitro...

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Bibliographic Details
Published in:Communications biology 2022-06, Vol.5 (1), p.538-538, Article 538
Main Authors: Zigo, Michal, Kerns, Karl, Sen, Sidharth, Essien, Clement, Oko, Richard, Xu, Dong, Sutovsky, Peter
Format: Article
Language:English
Subjects:
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Animals
Biology
Biomedical and Life Sciences
Capacitation
Contraception
Female
Fertility
Homeostasis
Life Sciences
Livestock
Male
Mammals
Movement disorders
Neurodegenerative diseases
Parkinson's disease
Plant Breeding
Reproduction
Reproductive health
Reproductive system
Sperm
Sperm Capacitation
Spermatozoa - metabolism
Swine
Zinc
Zinc - metabolism
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Summary:Sperm capacitation is a post-testicular maturation step endowing spermatozoa with fertilizing capacity within the female reproductive tract, significant for fertility, reproductive health, and contraception. Recently discovered mammalian sperm zinc signatures and their changes during sperm in vitro capacitation (IVC) warranted a more in-depth study of zinc interacting proteins (further zincoproteins). Here, we identified 1752 zincoproteins, with 102 changing significantly in abundance (P 
ISSN:2399-3642
2399-3642
DOI:10.1038/s42003-022-03485-8