Mitochondrial and nuclear genomics and the emergence of personalized medicine

Developing early detection biosensors for disease has been the long‒held goal of the Human Genome Project, but with little success. Conversely, the biological properties of the mitochondrion coupled with the relative simplicity of the mitochondrial genome give this organelle extraordinary functional...

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Bibliographic Details
Published in:Human genomics 2012-07, Vol.6 (1), p.3-3, Article 3
Main Authors: Parr, Ryan L, Martin, Luis H
Format: Article
Language:English
Subjects:
Biosensor
Cancerization field
Cell Nucleus - genetics
Genetic Predisposition to Disease - genetics
Genome, Mitochondrial - genetics
Genome-Wide Association Study - methods
Genome-Wide Association Study - trends
Genomic deletions
Genomics - methods
Heteroplasmy
Humans
Mitochondrial genomics
Mitogenome
Precision medicine
Precision Medicine - methods
Precision Medicine - trends
Prognosis
Review
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Summary:Developing early detection biosensors for disease has been the long‒held goal of the Human Genome Project, but with little success. Conversely, the biological properties of the mitochondrion coupled with the relative simplicity of the mitochondrial genome give this organelle extraordinary functionality as a biosensor and places the field of mitochondrial genomics in a position of strategic advantage to launch significant advances in personalized medicine. Numerous factors make the mitochondrion organelle uniquely suited to be an early detection biosensor with applications in oncology as well as many other aspects of human health and disease. Early detection of disease translates into more effective, less expensive treatments for disease and overall better prognoses for those at greater risk for developing diseases.
ISSN:1479-7364
1473-9542
1479-7364
DOI:10.1186/1479-7364-6-3