Piceatannol: A Potential futuristic natural stilbene as fetal haemoglobin inducer

Beta thalassemia is an autosomal recessive blood disorder results in abnormal formation of haemoglobin molecule and ineffective erythropoiesis. Patients need to be dependent on habitual blood transfusion and on unaffordable exorbitant therapies for continued existence. It is hypothesized if the leve...

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Bibliographic Details
Published in:Mediterranean journal of hematology and infectious diseases 2014-08, Vol.1
Main Authors: Aayush Kukreja, Samarth Tandon, Amit Mishra, Archana Tiwari
Format: Article
Language:English
Subjects:
Beta thalassemia
fetal haemoglobin inducer
piceatannol
stilbene
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Summary:Beta thalassemia is an autosomal recessive blood disorder results in abnormal formation of haemoglobin molecule and ineffective erythropoiesis. Patients need to be dependent on habitual blood transfusion and on unaffordable exorbitant therapies for continued existence. It is hypothesized if the level of fetal haemoglobin increases it compensates the need of adult haemoglobin and hence ameliorates clinical symptoms associated with beta thalassemia major. Illation from previous studies proves reactivation of fetal haemoglobin by the aid of natural compounds is a better alternative therapy in beta thalassemia patients because of its cost effectiveness and occurrence in natural eatables. Piceatannol, a naturally occurring stilbene, is less studied compound in comparison to resveratrol but shows a wide range of biological activities. This review paper is mainly focused on piceatannol and how it may be used as inducer of fetal haemoglobin in near future as a better compound than resveratrol.
ISSN:2035-3006