Expression of Long Non-Coding RNA H19 in Acute Lymphoblastic Leukemia

OObjective: Long non-coding RNA (lncRNA) H19 has essential roles in growth, migration, invasion, and metastasis of most cancers. H19 dysregulation is present in a large number of solid tumors and leukemia. However, the expression level of H19 in acute lymphoblastic leukemia (ALL) has not been elucid...

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Bibliographic Details
Published in:Cell journal (Yakhteh) 2023-01, Vol.25 (1), p.1-10
Main Authors: Asadi, Marjan, Gholampour, Mohammad Ali, Kompani, Farzad, Alizadeh, Shaban
Format: Article
Language:English
Subjects:
Actin
Acute lymphoblastic leukemia
Asparaginase
Bone marrow
c-Myc protein
Chemotherapy
Gene expression
h19
Hypoxia
Hypoxia-inducible factor 1a
L-asparaginase
Leukemia
lncrna
Lymphocytes B
Lymphocytes T
Metastases
Myc protein
Non-coding RNA
Original
p53 Protein
Pathogenesis
Polymerase chain reaction
Ribonucleic acid
RNA
Solid tumors
Therapeutic targets
Transcription factors
Tumors
Vincristine
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Summary:OObjective: Long non-coding RNA (lncRNA) H19 has essential roles in growth, migration, invasion, and metastasis of most cancers. H19 dysregulation is present in a large number of solid tumors and leukemia. However, the expression level of H19 in acute lymphoblastic leukemia (ALL) has not been elucidated yet. The current study aimed to explore expression in ALL patients and cell lines. This experimental study was conducted in bone marrow (BM) samples collected from 25 patients with newly diagnosed ALL. In addition, we cultured the RPMI-8402, Jurkat, Ramos, and Daudi cell lines and assessed the effects of internal (hypoxia) and external (chemotherapy medications L-asparaginase [ASP] and vincristine [VCR]) factors on h19 expression. The expressions of and were performed using quantitative real-time polymerase chain reaction (qRT-PCR) method. There was significantly increased expression in the B-cell ALL (B-ALL, P
ISSN:2228-5806
2228-5814
DOI:10.22074/cellj.2022.8315