Klotho and Fibroblast Growth Factor 23 Are Independent of Vitamin D, and Unlike Vitamin D, Are Not Associated With Graft- and Patient Survival After Kidney Transplantation

Short-term survival after kidney transplantation is excellent but long-term survival remains suboptimal. The aim of the study was to explore the relationship between soluble α-Klotho (sKlotho) and intact fibroblast growth factor 23 (iFGF23) measured 8 wk and 1 y posttransplant with long-term graft-...

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Bibliographic Details
Published in:Transplantation direct 2023-09, Vol.9 (9), p.e1522-e1522
Main Authors: Thorsen, Inga Strand, Bleskestad, Inger Hjørdis, Åsberg, Anders, Jonsson, Grete, Skadberg, Øyvind, Heldal, Kristian, Gøransson, Lasse Gunnar
Format: Article
Language:English
Subjects:
Kidney Transplantation
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Summary:Short-term survival after kidney transplantation is excellent but long-term survival remains suboptimal. The aim of the study was to explore the relationship between soluble α-Klotho (sKlotho) and intact fibroblast growth factor 23 (iFGF23) measured 8 wk and 1 y posttransplant with long-term graft- and patient survival in a cohort of kidney transplant recipients with deficient and nondeficient vitamin D (25[OH]D) levels. Vitamin D, sKlotho, and iFGF23 were measured 8 wk and 1 y posttransplant in 132 recipients transplanted between November 2012 and October 2013. Of the 132 kidney transplant recipients, 49 had deficient vitamin D levels (
ISSN:2373-8731
2373-8731
DOI:10.1097/TXD.0000000000001522