In Vitro Enzyme Inhibition Potentials and Antioxidant Activity of Synthetic Flavone Derivatives

Free radicals are produced by an important chemical process known as oxidation that in turn initiates chain reactions to damage the cells and originate oxidative stress. Flavones have got special position in research field of natural and synthetic organic chemistry due to their biological capabiliti...

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Bibliographic Details
Published in:Journal of chemistry 2015-01, Vol.2015 (2015), p.1-7
Main Authors: Akhtar, Sohail, Tahir, Muhammad Nawaz, Shafiullah, Muhammad, Naveed Umar, Muhammad, Shah, Ismail, Ali, Niaz, Ali Shah, Syed Wadood, Shoaib, Mohammad, Ayaz, Muhammad
Format: Article
Language:English
Subjects:
Bioflavonoids
Control
Flavones
Flavonoids
Free radicals (Chemistry)
Health aspects
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Summary:Free radicals are produced by an important chemical process known as oxidation that in turn initiates chain reactions to damage the cells and originate oxidative stress. Flavones have got special position in research field of natural and synthetic organic chemistry due to their biological capabilities as antioxidant. The antioxidants are known to possess extensive biological effects that include antiviral, antibacterial, anti-inflammatory, antithrombotic, and vasodilatory activities. The simple flavone (F1) and substituted flavone derivatives (F2–F5) have been synthesized from o-hydroxyacetophenone and benzaldehyde derivatives in good yield. The structures have been established by different spectroscopic techniques like 1H NMR, 13C NMR, IR, and elemental analysis. Antioxidant profile of these compounds was established using DPPH and H2O2 free radical scavenging assay. The findings showed that halogenated flavones showed more enzyme inhibitions and antioxidant activities than simple flavones and are potential candidates for the treatment of wide range of diseases.
ISSN:2090-9063
2090-9071
DOI:10.1155/2015/516878