Prevalence of JC polyomavirus among rheumatoid arthritis and systemic lupus erythematosus patients and its correlation with vitamin D levels

Vitamin D deficiency in viral infection associated with autoimmune diseases is well documented. This study assessed the prevalence of JC virus in patients with rheumatoid arthritis (RA) and systemic lupus erythematosus (SLE), and its correlation with vitamin D level. Serum and urine samples were col...

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Bibliographic Details
Published in:Iranian journal of microbiology 2024-10, Vol.16 (5), p.676-683
Main Authors: Irani Mokhtari, Golnaz, Azaran, Azarakhsh, Rajahi, Elham, Hesam, Saeed, Dehghani Ghahfarokhi, Azam, Makvandi, Manoochehr
Format: Article
Language:English
Subjects:
Arthritis
JC virus
Lupus erythematosus
Original
Polymerase chain reaction
Rheumatoid
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Summary:Vitamin D deficiency in viral infection associated with autoimmune diseases is well documented. This study assessed the prevalence of JC virus in patients with rheumatoid arthritis (RA) and systemic lupus erythematosus (SLE), and its correlation with vitamin D level. Serum and urine samples were collected from 50 patients with RA and SLE. DNA was extracted and subjected to PCR test. Positive PCR products were sequenced, phylogenetic tree was constructed to determine the JC virus genotype. The patient's vitamin D level was evaluated. Of 50 patients, 19 (38%) were diagnosed as RA, and 31 (62%) were identified as SLE. JC virus DNA was detected in 17 (34%) patients' urine samples including 5 (26.3%) RA and 12 (38.7%) SLE cases. JC virus DNA was detected 2 (4%) in patients' serum samples (one RA. and one SLE). JC virus genotype 3A was dominant. Interestingly, the SLE patients with positive JC virus showed lowered vitamin D compared to patients with negative JC virus (P
ISSN:2008-3289
2008-4447
DOI:10.18502/ijm.v16i5.16803