IL-26, a Cytokine With Roles in Extracellular DNA-Induced Inflammation and Microbial Defense

Interleukin 26 (IL-26) is the most recently identified member of the IL-20 cytokine subfamily, and is a novel mediator of inflammation overexpressed in activated or transformed T cells. Novel properties have recently been assigned to IL-26, owing to its non-conventional cationic, and amphipathic fea...

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Bibliographic Details
Published in:Frontiers in immunology 2019-02, Vol.10, p.204-204
Main Authors: Larochette, Vincent, Miot, Charline, Poli, Caroline, Beaumont, Elodie, Roingeard, Philippe, Fickenscher, Helmut, Jeannin, Pascale, Delneste, Yves
Format: Article
Language:English
Subjects:
Animals
Cancer
Cytokines - chemistry
Cytokines - genetics
Cytokines - metabolism
Disease Susceptibility
DNA carrier
Extracellular Space - genetics
Extracellular Space - immunology
Extracellular Space - metabolism
Gene Expression Regulation
Host-Pathogen Interactions - immunology
Humans
IL-26
Immunology
inflammation
Inflammation - etiology
Inflammation - metabolism
Inflammation - pathology
Inflammation Mediators - metabolism
Interleukins - chemistry
Interleukins - genetics
Interleukins - metabolism
kinocidin
Life Sciences
Signal Transduction
soluble PRM
Structure-Activity Relationship
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Summary:Interleukin 26 (IL-26) is the most recently identified member of the IL-20 cytokine subfamily, and is a novel mediator of inflammation overexpressed in activated or transformed T cells. Novel properties have recently been assigned to IL-26, owing to its non-conventional cationic, and amphipathic features. IL-26 binds to DNA released from damaged cells and, as a carrier molecule for extracellular DNA, links DNA to inflammation. This observation suggests that IL-26 may act both as a driver and an effector of inflammation, leading to the establishment of a deleterious amplification loop and, ultimately, sustained inflammation. Thus, IL-26 emerges as an important mediator in local immunity/inflammation. The dysregulated expression and extracellular DNA carrier capacity of IL-26 may have profound consequences for the chronicity of inflammation. IL-26 also exhibits direct antimicrobial properties. This review summarizes recent advances on the biology of IL-26 and discusses its roles as a novel kinocidin.
ISSN:1664-3224
1664-3224
DOI:10.3389/fimmu.2019.00204