Predicting Cross-Reactivity and Antigen Specificity of T Cell Receptors

Adaptive immune recognition is mediated by specific interactions between heterodimeric T cell receptors (TCRs) and their cognate peptide-MHC (pMHC) ligands, and the methods to accurately predict TCR:pMHC interaction would have profound clinical, therapeutic and pharmaceutical applications. Herein, w...

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Bibliographic Details
Published in:Frontiers in immunology 2020-10, Vol.11, p.565096-565096
Main Authors: Lee, Chloe H, Salio, Mariolina, Napolitani, Giorgio, Ogg, Graham, Simmons, Alison, Koohy, Hashem
Format: Article
Language:English
Subjects:
adaptive immune system
Animals
Antigen Presentation
antigen specificity
Antigens - immunology
Cross Reactions
epitope
Epitopes, T-Lymphocyte - immunology
Humans
Immunology
Kinetics
Ligands
Peptides - immunology
Protein Binding
Receptors, Antigen, T-Cell - immunology
T cell cross reactivity
T cell specificity
T-Lymphocytes - immunology
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Summary:Adaptive immune recognition is mediated by specific interactions between heterodimeric T cell receptors (TCRs) and their cognate peptide-MHC (pMHC) ligands, and the methods to accurately predict TCR:pMHC interaction would have profound clinical, therapeutic and pharmaceutical applications. Herein, we review recent developments in predicting cross-reactivity and antigen specificity of TCR recognition. We discuss current experimental and computational approaches to investigate cross-reactivity and antigen-specificity of TCRs and highlight how integrating kinetic, biophysical and structural features may offer valuable insights in modeling immunogenicity. We further underscore the close inter-relationship of these two interconnected notions and the need to investigate each in the light of the other for a better understanding of T cell responsiveness for the effective clinical applications.
ISSN:1664-3224
1664-3224
DOI:10.3389/fimmu.2020.565096