Maintenance electroconvulsive therapy for comorbid pharmacotherapy-refractory obsessive-compulsive and schizoaffective disorder

There is a high comorbidity of schizophrenia and obsessive-compulsory disorder (OCD) associated with more severe symptoms. Standard pharmacotherapy achieve symptom improvement in approximately 60% only. We report about a 48-old women treated for depression which developed successively psychotic symp...

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Bibliographic Details
Published in:European journal of medical research 2009-08, Vol.14 (8), p.367-368
Main Authors: Hanisch, F, Friedemann, J, Piro, J, Gutmann, P
Format: Article
Language:English
Subjects:
Antipsychotic drugs
atypical neuroleptics
Case Report
Comorbidity
Depression, Mental
Drug Resistance
Drug therapy
Electroconvulsive Therapy
Female
Humans
Middle Aged
Obsessive-compulsive disorder
Obsessive-Compulsive Disorder - psychology
Obsessive-Compulsive Disorder - therapy
Schizophrenia
Schizophrenia - therapy
Schizophrenic Psychology
Treatment Outcome
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Summary:There is a high comorbidity of schizophrenia and obsessive-compulsory disorder (OCD) associated with more severe symptoms. Standard pharmacotherapy achieve symptom improvement in approximately 60% only. We report about a 48-old women treated for depression which developed successively psychotic symptoms (ideas of reference, psychotic worries), negative symptoms (blunted affect, impoverished thinking, difficulties in planning), and obsessive-compulsive symptoms (mainly repeating rituals, avoidance behaviour, collecting and hoarding). She did not respond to combined treatment with neuroleptics and high dose selective serotonin re-uptake inhibitors. She acutely improved during a course of electroconvulsive therapy (ECT) and was maintained on outpatient ECTs fortnightly together with 12 mg sertindol and 45 mg mirtazapine for 42 weeks. Maintenance ECT is not an approved therapy in OCD but might be an option in pharmacotherapy refractory cases of comorbid OCD and schizophrenic/schizoaffective disorder.
ISSN:0949-2321
2047-783X
2047-783X
DOI:10.1186/2047-783x-14-8-367