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Bioprocess systems engineering: transferring traditional process engineering principles to industrial biotechnology

The complexity of the regulatory network and the interactions that occur in the intracellular environment of microorganisms highlight the importance in developing tractable mechanistic models of cellular functions and systematic approaches for modelling biological systems. To this end, the existing...

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Bibliographic Details
Published in:Computational and structural biotechnology journal 2012-10, Vol.3 (4), p.e201210022
Main Authors: Michalis Koutinas, Alexandros Kiparissides, Efstratios N Pistikopoulos, Athanasios Mantalaris
Format: Article
Language:English
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Summary:The complexity of the regulatory network and the interactions that occur in the intracellular environment of microorganisms highlight the importance in developing tractable mechanistic models of cellular functions and systematic approaches for modelling biological systems. To this end, the existing process systems engineering approaches can serve as a vehicle for understanding, integrating and designing biological systems and processes. Here, we review the application of a holistic approach for the development of mathematical models of biological systems, from the initial conception of the model to its final application in model-based control & optimisation. We also discuss the use of mechanistic models that account for gene regulation, in an attempt to advance the empirical expressions traditionally used to describe micro-organism growth kinetics, and we highlight current and future challenges in mathematical biology. The modelling research framework discussed herein could prove beneficial for the design of optimal bioprocesses, employing rational and feasible approaches towards the efficient production of chemicals and pharmaceuticals.
ISSN:2001-0370
2001-0370