Wine pomace product ameliorates hypertensive and diabetic aorta vascular remodeling through antioxidant and anti-inflammatory actions

[Display omitted] •Vascular remodelling is associated to hypertension and diabetes.•Vascular remodeling have oxidative and inflammatory alterations.•Wine pomace attenuates vascular remodeling by amelioration of oxidative stress.•Wine pomace reduces aortic thickness of SHRs and streptozotocin-diabeti...

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Bibliographic Details
Published in:Journal of functional foods 2020-03, Vol.66, p.103794, Article 103794
Main Authors: Gerardi, Gisela, Cavia-Saiz, Mónica, del Pino-García, Raquel, Rivero-Pérez, María D., González-SanJosé, María L., Muñiz, Pilar
Format: Article
Language:English
Subjects:
Aorta
Diabetes
eNOS
Hypertension
Vascular remodeling
Wine pomace product
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Summary:[Display omitted] •Vascular remodelling is associated to hypertension and diabetes.•Vascular remodeling have oxidative and inflammatory alterations.•Wine pomace attenuates vascular remodeling by amelioration of oxidative stress.•Wine pomace reduces aortic thickness of SHRs and streptozotocin-diabetic rats.•Wine pomace increase eNOS in aorta of SHRs and streptozotocin-diabetic rats. Vascular remodeling in hypertension and diabetes is characterized by a low-grade inflammation of the arterial wall and enhanced oxidative stress. Wine pomace products attenuate hyperglycemia and hypertension through reduction of oxidative stress and inflammation by their polyphenol composition. The aim of the study was to assess the influence of the wine pomace product (WP) on morphometric parameters of the arterial wall in spontaneously hypertensive rats (SHRs) and streptozotocin-diabetic rats (STZ). Oxidative stress was also evaluated by determination of radical oxygen species (ROS) and endothelial nitric oxide synthase (eNOS) activation in thoracic aortas. Wine pomace reduces wall aortic thickness, cross sectional area and wall/lumen ratio, and decreases ROS and increases eNOS activation. In summary, the supplementation of hypertensive or diabetic rats with the wine pomace product exhibits a protective role against the endothelial dysfunction and vascular remodeling.
ISSN:1756-4646
2214-9414
DOI:10.1016/j.jff.2020.103794