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Prevalence of hepatitis B core antibodies with negative hepatitis B surface antigen in dialysis and chronic kidney disease patients
Occult hepatitis B infection (OBI) is a potential cause of infection transmission in patients with chronic kidney disease (CKD) and dialysis-dependant patients. It is liable to be missed since the marker for OBI, hepatitis B core antibody (HBcAb), is not done routinely. We carried out a study to ass...
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| Published in: | Saudi journal of kidney diseases and transplantation 2017-07, Vol.28 (4), p.869-873 |
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| container_title | Saudi journal of kidney diseases and transplantation |
| container_volume | 28 |
| creator | Tarif, Nauman Riyad, Muhammad Muhsin Sabir, Umar Akhter, Radwan Rafiq, Kashif Rizvi, Nabiha |
| description | Occult hepatitis B infection (OBI) is a potential cause of infection transmission in
patients with chronic kidney disease (CKD) and dialysis-dependant patients. It is liable to be
missed since the marker for OBI, hepatitis B core antibody (HBcAb), is not done routinely. We
carried out a study to assess the prevalence of OBI in CKD Stage II–V or requiring renal
replacement therapy. It was a cross-sectional study carried out at Fatima Memorial Hospital,
Lahore, from May 2104 to May 2015. A total of 188 patients were included in this study, 124
were dialysis dependent and 64 had acute or CKD Stage II–V. About 17.55% (n = 33) of patients
had isolated HBcAb positive. Nearly 33.5% (n = 63) of patients were found to have hepatitis B
surface antigen positive, indicating development of immunity by exposure to virus. About
20.74% (n = 39) of patients were co-positive with HBcAb also. The prevalence of isolated
HBcAb in dialysis and CKD patients is high; therefore, testing for HBcAb should be a routine
part of screening in our CKD population to rule out OBI. Further confirmation with polymerase
chain reaction analysis for HBV viral DNA is recommended. Considering our circumstances, a
consensus statement from the hepatologists and nephrologists is needed to further plan for the
management of such cases |
| format | article |
| fullrecord | <record><control><sourceid>gale_doaj_</sourceid><recordid>TN_cdi_doaj_primary_oai_doaj_org_article_7ed847b0a6e743a98608c35870bfc1b3</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><galeid>A499645708</galeid><doaj_id>oai_doaj_org_article_7ed847b0a6e743a98608c35870bfc1b3</doaj_id><sourcerecordid>A499645708</sourcerecordid><originalsourceid>FETCH-LOGICAL-d425t-e5026a371e6ede0bf4aa671d7587c0b6cc4e10edf464126e978025bed774223d3</originalsourceid><addsrcrecordid>eNptkk1v1DAQhiMEokvhJ4AsISEuQY7t2M6xVHxUqgQHOEcTe7LxkrUX22m15_7xumwpLEI-jPTOM-_YM35UrRhntOaa68fVquFNVzMh2En1LKUNpW3bSfm0OmFaCa07uqpuvka8ghm9QRJGMuEOsssukffEhIgEfHZDsA4TuXZ5Ih7XBbjCIzItcQRzgNfoifPEOpj3qWTBW2KmGLwz5IezHvcllxASkjsD9Dk9r56MMCd8cR9Pq-8fP3w7_1xffvl0cX52WVvB2lxjS5kErhqUaJEOowCQqrGq1crQQRojsKFoRyFFwyR2SlPWDmiVEoxxy0-ri4OvDbDpd9FtIe77AK7_JYS47iFmZ2bsFVot1EBBohIcOi2pNrw0Km1NM_Di9fbgtYvh54Ip91uXDM4zeAxL6puOibbjnW4L-vofdBOW6MtLC8Vlo8tS2B9qXbbROz-GHMHcmfZnouukaBXVhXr3H6oci1tngsfRFf2o4M1fBRPCnKcU5iW74NMx-Or-lsuwRfswnt9fpQAvDwAWHUd4IJSSTcv4LQtTw1I</addsrcrecordid><sourcetype>Open Website</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>1936185962</pqid></control><display><type>article</type><title>Prevalence of hepatitis B core antibodies with negative hepatitis B surface antigen in dialysis and chronic kidney disease patients</title><source>Publicly Available Content Database</source><source>Medknow Open Access Medical Journals</source><creator>Tarif, Nauman ; Riyad, Muhammad Muhsin ; Sabir, Umar ; Akhter, Radwan ; Rafiq, Kashif ; Rizvi, Nabiha</creator><creatorcontrib>Tarif, Nauman ; Riyad, Muhammad Muhsin ; Sabir, Umar ; Akhter, Radwan ; Rafiq, Kashif ; Rizvi, Nabiha</creatorcontrib><description>Occult hepatitis B infection (OBI) is a potential cause of infection transmission in
patients with chronic kidney disease (CKD) and dialysis-dependant patients. It is liable to be
missed since the marker for OBI, hepatitis B core antibody (HBcAb), is not done routinely. We
carried out a study to assess the prevalence of OBI in CKD Stage II–V or requiring renal
replacement therapy. It was a cross-sectional study carried out at Fatima Memorial Hospital,
Lahore, from May 2104 to May 2015. A total of 188 patients were included in this study, 124
were dialysis dependent and 64 had acute or CKD Stage II–V. About 17.55% (n = 33) of patients
had isolated HBcAb positive. Nearly 33.5% (n = 63) of patients were found to have hepatitis B
surface antigen positive, indicating development of immunity by exposure to virus. About
20.74% (n = 39) of patients were co-positive with HBcAb also. The prevalence of isolated
HBcAb in dialysis and CKD patients is high; therefore, testing for HBcAb should be a routine
part of screening in our CKD population to rule out OBI. Further confirmation with polymerase
chain reaction analysis for HBV viral DNA is recommended. Considering our circumstances, a
consensus statement from the hepatologists and nephrologists is needed to further plan for the
management of such cases</description><identifier>ISSN: 1319-2442</identifier><identifier>EISSN: 2320-3838</identifier><identifier>PMID: 28748890</identifier><language>eng</language><publisher>Riyadh, Saudi Arabia: Saudi Center for Organ Transplantation</publisher><subject>Antigens ; Blood & organ donations ; Care and treatment ; Chronic kidney failure ; Deoxyribonucleic acid ; Developing countries ; Disease control ; Disease prevention ; DNA ; Health aspects ; Health sciences ; Hemodialysis ; Hepatitis ; Hepatitis B ; Hospitals ; Infections ; Kidney diseases ; LDCs ; Medicine ; Nephrology ; Patients ; Population ; Renal replacement therapy ; Studies ; Transplants & implants ; الأجسام المضادة ; الأمراض ; التهاب الكبد ب ; الكلى ; غسيل الكلى</subject><ispartof>Saudi journal of kidney diseases and transplantation, 2017-07, Vol.28 (4), p.869-873</ispartof><rights>COPYRIGHT 2017 Medknow Publications and Media Pvt. Ltd.</rights><rights>Copyright Medknow Publications & Media Pvt. Ltd. Jul/Aug 2017</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://www.proquest.com/docview/1936185962?pq-origsite=primo$$EHTML$$P50$$Gproquest$$Hfree_for_read</linktohtml><link.rule.ids>314,776,780,25733,36991,36992,44569</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/28748890$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Tarif, Nauman</creatorcontrib><creatorcontrib>Riyad, Muhammad Muhsin</creatorcontrib><creatorcontrib>Sabir, Umar</creatorcontrib><creatorcontrib>Akhter, Radwan</creatorcontrib><creatorcontrib>Rafiq, Kashif</creatorcontrib><creatorcontrib>Rizvi, Nabiha</creatorcontrib><title>Prevalence of hepatitis B core antibodies with negative hepatitis B surface antigen in dialysis and chronic kidney disease patients</title><title>Saudi journal of kidney diseases and transplantation</title><addtitle>Saudi J Kidney Dis Transpl</addtitle><description>Occult hepatitis B infection (OBI) is a potential cause of infection transmission in
patients with chronic kidney disease (CKD) and dialysis-dependant patients. It is liable to be
missed since the marker for OBI, hepatitis B core antibody (HBcAb), is not done routinely. We
carried out a study to assess the prevalence of OBI in CKD Stage II–V or requiring renal
replacement therapy. It was a cross-sectional study carried out at Fatima Memorial Hospital,
Lahore, from May 2104 to May 2015. A total of 188 patients were included in this study, 124
were dialysis dependent and 64 had acute or CKD Stage II–V. About 17.55% (n = 33) of patients
had isolated HBcAb positive. Nearly 33.5% (n = 63) of patients were found to have hepatitis B
surface antigen positive, indicating development of immunity by exposure to virus. About
20.74% (n = 39) of patients were co-positive with HBcAb also. The prevalence of isolated
HBcAb in dialysis and CKD patients is high; therefore, testing for HBcAb should be a routine
part of screening in our CKD population to rule out OBI. Further confirmation with polymerase
chain reaction analysis for HBV viral DNA is recommended. Considering our circumstances, a
consensus statement from the hepatologists and nephrologists is needed to further plan for the
management of such cases</description><subject>Antigens</subject><subject>Blood & organ donations</subject><subject>Care and treatment</subject><subject>Chronic kidney failure</subject><subject>Deoxyribonucleic acid</subject><subject>Developing countries</subject><subject>Disease control</subject><subject>Disease prevention</subject><subject>DNA</subject><subject>Health aspects</subject><subject>Health sciences</subject><subject>Hemodialysis</subject><subject>Hepatitis</subject><subject>Hepatitis B</subject><subject>Hospitals</subject><subject>Infections</subject><subject>Kidney diseases</subject><subject>LDCs</subject><subject>Medicine</subject><subject>Nephrology</subject><subject>Patients</subject><subject>Population</subject><subject>Renal replacement therapy</subject><subject>Studies</subject><subject>Transplants & implants</subject><subject>الأجسام المضادة</subject><subject>الأمراض</subject><subject>التهاب الكبد ب</subject><subject>الكلى</subject><subject>غسيل الكلى</subject><issn>1319-2442</issn><issn>2320-3838</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2017</creationdate><recordtype>article</recordtype><sourceid>PIMPY</sourceid><sourceid>DOA</sourceid><recordid>eNptkk1v1DAQhiMEokvhJ4AsISEuQY7t2M6xVHxUqgQHOEcTe7LxkrUX22m15_7xumwpLEI-jPTOM-_YM35UrRhntOaa68fVquFNVzMh2En1LKUNpW3bSfm0OmFaCa07uqpuvka8ghm9QRJGMuEOsssukffEhIgEfHZDsA4TuXZ5Ih7XBbjCIzItcQRzgNfoifPEOpj3qWTBW2KmGLwz5IezHvcllxASkjsD9Dk9r56MMCd8cR9Pq-8fP3w7_1xffvl0cX52WVvB2lxjS5kErhqUaJEOowCQqrGq1crQQRojsKFoRyFFwyR2SlPWDmiVEoxxy0-ri4OvDbDpd9FtIe77AK7_JYS47iFmZ2bsFVot1EBBohIcOi2pNrw0Km1NM_Di9fbgtYvh54Ip91uXDM4zeAxL6puOibbjnW4L-vofdBOW6MtLC8Vlo8tS2B9qXbbROz-GHMHcmfZnouukaBXVhXr3H6oci1tngsfRFf2o4M1fBRPCnKcU5iW74NMx-Or-lsuwRfswnt9fpQAvDwAWHUd4IJSSTcv4LQtTw1I</recordid><startdate>20170701</startdate><enddate>20170701</enddate><creator>Tarif, Nauman</creator><creator>Riyad, Muhammad Muhsin</creator><creator>Sabir, Umar</creator><creator>Akhter, Radwan</creator><creator>Rafiq, Kashif</creator><creator>Rizvi, Nabiha</creator><general>Saudi Center for Organ Transplantation</general><general>Medknow Publications and Media Pvt. 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Ltd</general><general>Wolters Kluwer Medknow Publications</general><scope>ADJCN</scope><scope>AHFXO</scope><scope>NPM</scope><scope>3V.</scope><scope>7RV</scope><scope>7X7</scope><scope>7XB</scope><scope>88E</scope><scope>8AO</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>AZQEC</scope><scope>BENPR</scope><scope>CCPQU</scope><scope>DWQXO</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>K9.</scope><scope>KB0</scope><scope>M0S</scope><scope>M1P</scope><scope>NAPCQ</scope><scope>PIMPY</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>PRINS</scope><scope>7X8</scope><scope>DOA</scope></search><sort><creationdate>20170701</creationdate><title>Prevalence of hepatitis B core antibodies with negative hepatitis B surface antigen in dialysis and chronic kidney disease patients</title><author>Tarif, Nauman ; Riyad, Muhammad Muhsin ; Sabir, Umar ; Akhter, Radwan ; Rafiq, Kashif ; Rizvi, Nabiha</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-d425t-e5026a371e6ede0bf4aa671d7587c0b6cc4e10edf464126e978025bed774223d3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2017</creationdate><topic>Antigens</topic><topic>Blood & organ donations</topic><topic>Care and treatment</topic><topic>Chronic kidney failure</topic><topic>Deoxyribonucleic acid</topic><topic>Developing countries</topic><topic>Disease control</topic><topic>Disease prevention</topic><topic>DNA</topic><topic>Health aspects</topic><topic>Health sciences</topic><topic>Hemodialysis</topic><topic>Hepatitis</topic><topic>Hepatitis B</topic><topic>Hospitals</topic><topic>Infections</topic><topic>Kidney diseases</topic><topic>LDCs</topic><topic>Medicine</topic><topic>Nephrology</topic><topic>Patients</topic><topic>Population</topic><topic>Renal replacement therapy</topic><topic>Studies</topic><topic>Transplants & implants</topic><topic>الأجسام المضادة</topic><topic>الأمراض</topic><topic>التهاب الكبد ب</topic><topic>الكلى</topic><topic>غسيل الكلى</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Tarif, Nauman</creatorcontrib><creatorcontrib>Riyad, Muhammad Muhsin</creatorcontrib><creatorcontrib>Sabir, Umar</creatorcontrib><creatorcontrib>Akhter, Radwan</creatorcontrib><creatorcontrib>Rafiq, Kashif</creatorcontrib><creatorcontrib>Rizvi, Nabiha</creatorcontrib><collection>الدوريات العلمية والإحصائية - 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Academic</collection><collection>Open Access: DOAJ - Directory of Open Access Journals</collection><jtitle>Saudi journal of kidney diseases and transplantation</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Tarif, Nauman</au><au>Riyad, Muhammad Muhsin</au><au>Sabir, Umar</au><au>Akhter, Radwan</au><au>Rafiq, Kashif</au><au>Rizvi, Nabiha</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Prevalence of hepatitis B core antibodies with negative hepatitis B surface antigen in dialysis and chronic kidney disease patients</atitle><jtitle>Saudi journal of kidney diseases and transplantation</jtitle><addtitle>Saudi J Kidney Dis Transpl</addtitle><date>2017-07-01</date><risdate>2017</risdate><volume>28</volume><issue>4</issue><spage>869</spage><epage>873</epage><pages>869-873</pages><issn>1319-2442</issn><eissn>2320-3838</eissn><abstract>Occult hepatitis B infection (OBI) is a potential cause of infection transmission in
patients with chronic kidney disease (CKD) and dialysis-dependant patients. It is liable to be
missed since the marker for OBI, hepatitis B core antibody (HBcAb), is not done routinely. We
carried out a study to assess the prevalence of OBI in CKD Stage II–V or requiring renal
replacement therapy. It was a cross-sectional study carried out at Fatima Memorial Hospital,
Lahore, from May 2104 to May 2015. A total of 188 patients were included in this study, 124
were dialysis dependent and 64 had acute or CKD Stage II–V. About 17.55% (n = 33) of patients
had isolated HBcAb positive. Nearly 33.5% (n = 63) of patients were found to have hepatitis B
surface antigen positive, indicating development of immunity by exposure to virus. About
20.74% (n = 39) of patients were co-positive with HBcAb also. The prevalence of isolated
HBcAb in dialysis and CKD patients is high; therefore, testing for HBcAb should be a routine
part of screening in our CKD population to rule out OBI. Further confirmation with polymerase
chain reaction analysis for HBV viral DNA is recommended. Considering our circumstances, a
consensus statement from the hepatologists and nephrologists is needed to further plan for the
management of such cases</abstract><cop>Riyadh, Saudi Arabia</cop><pub>Saudi Center for Organ Transplantation</pub><pmid>28748890</pmid><tpages>5</tpages><oa>free_for_read</oa></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 1319-2442 |
| ispartof | Saudi journal of kidney diseases and transplantation, 2017-07, Vol.28 (4), p.869-873 |
| issn | 1319-2442 2320-3838 |
| language | eng |
| recordid | cdi_doaj_primary_oai_doaj_org_article_7ed847b0a6e743a98608c35870bfc1b3 |
| source | Publicly Available Content Database; Medknow Open Access Medical Journals |
| subjects | Antigens Blood & organ donations Care and treatment Chronic kidney failure Deoxyribonucleic acid Developing countries Disease control Disease prevention DNA Health aspects Health sciences Hemodialysis Hepatitis Hepatitis B Hospitals Infections Kidney diseases LDCs Medicine Nephrology Patients Population Renal replacement therapy Studies Transplants & implants الأجسام المضادة الأمراض التهاب الكبد ب الكلى غسيل الكلى |
| title | Prevalence of hepatitis B core antibodies with negative hepatitis B surface antigen in dialysis and chronic kidney disease patients |
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