An Updated View of the Importance of Vesicular Trafficking and Transport and Their Role in Immune-Mediated Diseases: Potential Therapeutic Interventions

Cellular trafficking is the set of processes of distributing different macromolecules by the cell. This process is highly regulated in cells, involving a system of organelles (endomembranous system), among which are a great variety of vesicles that can be secreted from the cell, giving rise to diffe...

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Published in:Membranes (Basel) 2022-05, Vol.12 (6), p.552
Main Authors: Ortega, Miguel A., Fraile-Martinez, Oscar, Garcia-Montero, Cielo, Alvarez-Mon, Miguel Angel, Gomez-Lahoz, Ana Maria, Albillos, Agustin, Lahera, Guillermo, Quintero, Javier, Monserrat, Jorge, Guijarro, Luis G., Alvarez-Mon, Melchor
Format: Article
Language:English
Subjects:
Biomarkers
Biosynthesis
Carbohydrates
cellular traffic
Communication
Endoplasmic reticulum
exosomes
Extracellular vesicles
Immune system
immune-mediated diseases
Lipids
Macromolecules
Organelles
Plasma
Proteins
Review
Therapeutic applications
Therapeutic targets
Translation
Vesicles
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container_title Membranes (Basel)
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creator Ortega, Miguel A.
Fraile-Martinez, Oscar
Garcia-Montero, Cielo
Alvarez-Mon, Miguel Angel
Gomez-Lahoz, Ana Maria
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Lahera, Guillermo
Quintero, Javier
Monserrat, Jorge
Guijarro, Luis G.
Alvarez-Mon, Melchor
description Cellular trafficking is the set of processes of distributing different macromolecules by the cell. This process is highly regulated in cells, involving a system of organelles (endomembranous system), among which are a great variety of vesicles that can be secreted from the cell, giving rise to different types of extracellular vesicles (EVs) that can be captured by other cells to modulate their function. The cells of the immune system are especially sensitive to this cellular traffic, producing and releasing different classes of EVs, especially in disease states. There is growing interest in this field due to the therapeutic and translational possibilities it offers. Different ways of taking advantage of the understanding of cell trafficking and EVs are being investigated, and their use as biomarkers or therapeutic targets is being investigated. The objective of this review is to collect the latest results and knowledge in this area with a specific focus on immune-mediated diseases. Although some promising results have been obtained, further knowledge is still needed, at both the basic and translational levels, to understand and modulate cellular traffic and EVs for better clinical management of these patients.
doi_str_mv 10.3390/membranes12060552
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subjects Biomarkers
Biosynthesis
Carbohydrates
cellular traffic
Communication
Endoplasmic reticulum
exosomes
Extracellular vesicles
Immune system
immune-mediated diseases
Lipids
Macromolecules
Organelles
Plasma
Proteins
Review
Therapeutic applications
Therapeutic targets
Translation
Vesicles
title An Updated View of the Importance of Vesicular Trafficking and Transport and Their Role in Immune-Mediated Diseases: Potential Therapeutic Interventions
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