Targeted protein delivery based on stimuli‐triggered nanomedicine

• Published in: Exploration (Beijing, China) China), 2024-06, Vol.4 (3), p.20230025-n/a
• Main Authors: Liu, Jinzhao, Zhou, Yang, Lyu, Qingyang, Yao, Xiaotong, Wang, Weiping
• Format: Article
• Language: English
• Subjects: protein delivery; protein‐based drugs; stimuli‐responsive nanoparticles; stimuli‐triggered targeting
• ISSN: 2766-8509; 2766-2098; 2766-2098
• DOI: 10.1002/EXP.20230025

Protein‐based drugs have shown unique advantages to treat various diseases in recent years. However, most protein therapeutics in clinical use are limited to extracellular targets with low delivery efficiency. To realize targeted protein delivery, a series of stimuli‐triggered nanoparticle formulations have been developed to improve delivery efficiency and reduce off‐target release. These smart nanoparticles are designed to release cargo proteins in response to either internal or external stimuli at pathological tissues. In this way, varieties of protein‐based drugs including antibodies, enzymes, and pro‐apoptotic proteins can be effectively delivered to desired sites for the treatment of cancer, inflammation, metabolic diseases, and so on with minimal side effects. In this review, recent advances in the design of stimuli‐triggered nanomedicine for targeted protein delivery in different biomedical applications will be discussed. A deeper understanding of these emerging strategies helps develop more efficient protein delivery systems for clinical use in the future. To realize targeted protein delivery, various stimuli‐triggered nanoparticle formulations have been developed. These smart nanoparticles are designed to release cargo proteins, such as antibodies, enzymes, and pro‐apoptotic proteins, in response to either internal or external stimuli. This review summarizes recent advances in the design of stimuli‐triggered nanomedicine for targeted protein delivery in different biomedical applications.