Chemo-enzymatic synthesis of a multi-useful chiral building block molecule for the synthesis of medicinal compounds

Optical resolution of 2-methyl-2-nitrobut-3-en-1-ol has been accomplished using a "low-temperature lipase-catalyzed transesterification" carried out at -40 °C.

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Bibliographic Details
Published in:Molecules (Basel, Switzerland) Switzerland), 2011-08, Vol.16 (8), p.6747-6757
Main Authors: Nakano, Toshiki, Yagi, Yusuke, Miyahara, Mizuki, Kaminura, Akio, Kawatsura, Motoi, Itoh, Toshiyuki
Format: Article
Language:English
Subjects:
Alcohol
Alcohols - chemistry
Amino acids
Bacterial Proteins - metabolism
Biological Products - chemical synthesis
Catalysis
Chemistry, Pharmaceutical
Chromatography, High Pressure Liquid
Chromatography, Thin Layer
Enzymes
Esterification
Fungal Proteins - metabolism
Kinetics
lipase
Lipase - metabolism
Magnetic Resonance Spectroscopy
nitro alcohol
optically active
Plant Proteins - metabolism
Protocol
quaternary chiral carbon
Stereoisomerism
synthesis
Temperature
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Description
Summary:Optical resolution of 2-methyl-2-nitrobut-3-en-1-ol has been accomplished using a "low-temperature lipase-catalyzed transesterification" carried out at -40 °C.
ISSN:1420-3049
1420-3049
DOI:10.3390/molecules16086747