Maternal and child-health outcomes in pregnancies following Assisted Reproductive Technology (ART): a prospective cohort study

Studies comparing the outcome of spontaneous versus assisted reproductive technologies (ART) pregnancies report heterogeneous results. Despite the success of ART to overcome infertility, concern is growing regarding both its safety and its effect on maternal and child health. The objective of this s...

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Bibliographic Details
Published in:BMC pregnancy and childbirth 2020-02, Vol.20 (1), p.106-106, Article 106
Main Authors: da Silva, Shana Ginar, da Silveira, Mariângela Freitas, Bertoldi, Andréa Dâmaso, Domingues, Marlos Rodrigues, Dos Santos, Iná da Silva
Format: Article
Language:English
Subjects:
Adult
Assisted reproductive technology
Birth Weight
Brazil
Childbirth & labor
Childrens health
Clinical outcomes
Cohort analysis
Cohort Studies
Delivery, Obstetric - statistics & numerical data
Female
Fertilization in Vitro - adverse effects
Fetal Growth Retardation - epidemiology
Gestational Age
Gestational Weight Gain
Health risk assessment
Humans
In vitro fertilization
Infant, Newborn
Maternal & child health
Neonatal outcomes
Newborn babies
Perinatal health
Pregnancy
Pregnancy Complications - epidemiology
Pregnancy Outcome - epidemiology
Pregnancy, Multiple
Premature Birth - epidemiology
Prospective Studies
Reproductive Techniques, Assisted - adverse effects
Reproductive technologies
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Summary:Studies comparing the outcome of spontaneous versus assisted reproductive technologies (ART) pregnancies report heterogeneous results. Despite the success of ART to overcome infertility, concern is growing regarding both its safety and its effect on maternal and child health. The objective of this study was to compare maternal and child-health outcomes after ART relative to natural conception. A population-based birth cohort study was carried out among pregnant women expected to deliver in 2015 in Pelotas, southern Brazil. Maternal outcomes included pregnancy complications and gestational weight gain. Gestational age, weight, intrauterine growth restriction, length and head circumference, and 1-min and 5-min Apgar, as well as health problems at birth and breastfeeding were defined as offspring outcomes. Statistical analyses were performed using linear and logistic regression. G-formula was used to perform mediation analysis. The study included 4252 babies born by spontaneously pregnancies and 23 babies born after ART. Adjusted analyses showed that children conceived from ART presented lower means of gestational age (p = 0.001), birth weight (p = 0.002), length (p 
ISSN:1471-2393
1471-2393
DOI:10.1186/s12884-020-2755-z