Roles of Traditional and Next-Generation Probiotics on Non-Alcoholic Fatty Liver Disease (NAFLD) and Non-Alcoholic Steatohepatitis (NASH): A Systematic Review and Network Meta-Analysis

Non-alcoholic fatty liver disease (NAFLD) and its progressive stage, non-alcoholic steatohepatitis (NASH), are becoming one of the most common chronic liver diseases globally. Lifestyle interventions such as weight reduction, increased physical activity, and maintaining healthy diets play a pivotal...

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Bibliographic Details
Published in:Antioxidants 2024-03, Vol.13 (3), p.329
Main Authors: Zhu, Yuezhi, Tan, Jen Kit, Liu, Jia, Goon, Jo Aan
Format: Article
Language:English
Subjects:
antioxidant
Clinical outcomes
Comparative analysis
Digestive system
Fatty acids
Fatty liver
Gastrointestinal tract
Hepatitis
Immune response
Inflammation
Intervention
Intestinal microflora
Lifestyles
Lipids
Liver diseases
Medical Subject Headings-MeSH
Meta-analysis
Metabolism
Microbiomes
Microbiota
NAFLD/NASH
next-generation probiotics (NGPs)
Oxidative stress
Patients
Physical activity
Prebiotics
Probiotics
Review
short-chain fatty acids (SCFAs)
Systematic review
traditional probiotics
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Summary:Non-alcoholic fatty liver disease (NAFLD) and its progressive stage, non-alcoholic steatohepatitis (NASH), are becoming one of the most common chronic liver diseases globally. Lifestyle interventions such as weight reduction, increased physical activity, and maintaining healthy diets play a pivotal role in managing NAFLD/NASH. Recent studies suggest that the gut microbiome is associated with the pathogenesis of NAFLD/NASH, prompting microbiome-targeted therapy to emerge as a new therapeutic option for NAFLD/NASH. We conducted a systematic review based on the PRISMA statement and employed network meta-analysis to investigate the effects of traditional probiotics and next-generation probiotics (NGPs) on NAFLD/NASH. Comparative analysis reveals that traditional probiotics primarily reduce liver fat deposition and inflammation by improving gut microbiota composition, enhancing intestinal barrier function, and modulating immune responses. In contrast, NGPs demonstrate a more significant therapeutic potential, attributed to their direct effects on inhibiting oxidative stress and their ability to enhance the production of short-chain fatty acids (SCFAs), NGPs appear as a new potential strategy for the management of NAFLD/NASH through their dual action of directly inhibiting oxidative stress and enhancing SCFA production, highlighting the importance of understanding and utilizing the direct and indirect regulatory mechanisms of oxidative stress in the management of NAFLD/NASH.
ISSN:2076-3921
2076-3921
DOI:10.3390/antiox13030329