Understanding CNS Effects of Antimicrobial Drugs Using Zebrafish Models

Antimicrobial drugs represent a diverse group of widely utilized antibiotic, antifungal, antiparasitic and antiviral agents. Their growing use and clinical importance necessitate our improved understanding of physiological effects of antimicrobial drugs, including their potential effects on the cent...

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Bibliographic Details
Published in:Veterinary sciences 2023-01, Vol.10 (2), p.96
Main Authors: Kotova, Maria M, Galstyan, David S, Kolesnikova, Tatiana O, de Abreu, Murilo S, Amstislavskaya, Tamara G, Strekalova, Tatyana, Petersen, Elena V, Yenkoyan, Konstantin B, Demin, Konstantin A, Kalueff, Allan V
Format: Article
Language:English
Subjects:
Animal cognition
Anti-infective agents
antibiotic
Antibiotics
Antimicrobial agents
antimicrobial drugs
Antiparasitic agents
Antiviral agents
Anxiety
Apoptosis
Behavior
brain
Brain research
Central nervous system
Danio rerio
DNA methylation
Dopamine
Drug dosages
Drug screening
Drugs
Epilepsy
Intestinal microflora
Kinases
Memory
Microbiota
Microbiota (Symbiotic organisms)
Neomycin
Neurophysiology
Neurotoxicity
Oxidative stress
Oxytetracycline
Parkinson's disease
Pathogenesis
Permeability
Physiological aspects
Physiology
Proteins
Review
Rodents
Serotonin
Thyroid gland
Zebrafish
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Summary:Antimicrobial drugs represent a diverse group of widely utilized antibiotic, antifungal, antiparasitic and antiviral agents. Their growing use and clinical importance necessitate our improved understanding of physiological effects of antimicrobial drugs, including their potential effects on the central nervous system (CNS), at molecular, cellular, and behavioral levels. In addition, antimicrobial drugs can alter the composition of gut microbiota, and hence affect the gut-microbiota-brain axis, further modulating brain and behavioral processes. Complementing rodent studies, the zebrafish ( ) emerges as a powerful model system for screening various antimicrobial drugs, including probing their putative CNS effects. Here, we critically discuss recent evidence on the effects of antimicrobial drugs on brain and behavior in zebrafish, and outline future related lines of research using this aquatic model organism.
ISSN:2306-7381
2306-7381
DOI:10.3390/vetsci10020096