New Vehiculation Systems of Mometasone Furoate for the Treatment of Inflammatory Skin Diseases

A pre-formulation study was carried out to obtain liposomal formulations of mometasone furoate as an alternative system to marketed forms of corticosteroid for the treatment of inflammatory skin lesions. Mometasone furoate was loaded in glycerosomes and glyceroethosomes, which were also modified wit...

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Bibliographic Details
Published in:Pharmaceutics 2022-11, Vol.14 (12), p.2558
Main Authors: Taléns-Visconti, Raquel, Perra, Matteo, Ruiz-Saurí, Amparo, Nácher, Amparo
Format: Article
Language:English
Subjects:
Dosage and administration
Drug delivery systems
Drug therapy
Drugs
Ethanol
glyceroethohyalurosomes
glyceroethosomes
Glycerol
glycerosomes
Hyaluronic acid
Inflammation
inflammatory lesions
Liposomes
Mometasone
mometasone furoate
Pharmaceutical research
Psoriasis
Skin diseases
Spectrum analysis
Steroids
Vehicles
Vitamin E
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Summary:A pre-formulation study was carried out to obtain liposomal formulations of mometasone furoate as an alternative system to marketed forms of corticosteroid for the treatment of inflammatory skin lesions. Mometasone furoate was loaded in glycerosomes and glyceroethosomes, which were also modified with hyaluronic acid (glyceroethohyalurosomes). Vesicles were designed, elaborated, and characterized, and their biocompatibility, efficacy against oxidative stress and skin lesions were assessed in vitro, in human epidermal cells, and in vivo, in a mouse skin epidermal hyperplasia model. All formulations tested showed great encapsulation efficiency, nanometric size, formed monodispersed systems and a highly negative Z potential. Similar values were obtained over nine months storage at 4 °C, which indicates the great stability of the three types of nanoliposomes at least during the time tested. Among them, 0.1% mometasone furoate glyceroethohyalurosomes were the best formulation to protect cells against oxidative stress and their anti-inflammatory efficacy was confirmed in vivo, being even more effective than the marketed form (Elocom ), as the reduction in the inflammation was even ~15% higher than that achieved with the commercial cream. Selected formulations could be potential candidates as new vehiculation systems for mometasone furoate. The presence of hyaluronic acid in glyceroethohyalurosomes makes them the best candidates in preventing/treating skin inflammatory lesions.
ISSN:1999-4923
1999-4923
DOI:10.3390/pharmaceutics14122558